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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2012 Volume 27 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Angiotensin-(1-7) inhibits the migration and invasion of A549 human lung adenocarcinoma cells through inactivation of the PI3K/Akt and MAPK signaling pathways

  • Authors:
    • Lei Ni
    • Yun Feng
    • Huanying Wan
    • Qinyun Ma
    • Liang Fan
    • Yanrong Qian
    • Qingyun Li
    • Yi Xiang
    • Beili Gao

  • View Affiliations / Copyright

    Affiliations: Department of Respiration, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Road II, Shanghai 200025, P.R. China
  • Pages: 783-790
    |
    Published online on: November 15, 2011
       https://doi.org/10.3892/or.2011.1554
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Abstract

The local renin-angiotensin system (RAS) is one of the crucial components in the tumor microenvironment. Recent evidence suggests that the local RAS plays an important role in tumor metabolism, survival, angiogenesis and invasion processes. Angiotensin-(1-7) [Ang-(1-7)] is an endogenous peptide of the RAS with vasodilator and anti-proliferative properties. Previous studies have demonstrated that Ang-(1-7) inhibits both the growth of human lung cancer cells in vitro and tumor angiogenesis in vivo through activation of the MAS receptor. This study investigated the anti-metastatic effect of Ang-(1-7) in A549 human lung adenocarcinoma cells in vitro. We found that Ang-(1-7) reduced the cell migratory and invasive abilities by reducing the expression and activity of MMP-2 and MMP-9. Furthermore, we demonstrated that the anti-migration and anti-invasion effect of Ang-(1-7) was mediated through inactivation of the PI3K/Akt, P38 and JNK signal pathways. Our results suggest that Ang-(1-7) may have therapeutic potential against advanced lung carcinoma as a new agent.

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Copy and paste a formatted citation
Spandidos Publications style
Ni L, Feng Y, Wan H, Ma Q, Fan L, Qian Y, Li Q, Xiang Y and Gao B: Angiotensin-(1-7) inhibits the migration and invasion of A549 human lung adenocarcinoma cells through inactivation of the PI3K/Akt and MAPK signaling pathways. Oncol Rep 27: 783-790, 2012.
APA
Ni, L., Feng, Y., Wan, H., Ma, Q., Fan, L., Qian, Y. ... Gao, B. (2012). Angiotensin-(1-7) inhibits the migration and invasion of A549 human lung adenocarcinoma cells through inactivation of the PI3K/Akt and MAPK signaling pathways. Oncology Reports, 27, 783-790. https://doi.org/10.3892/or.2011.1554
MLA
Ni, L., Feng, Y., Wan, H., Ma, Q., Fan, L., Qian, Y., Li, Q., Xiang, Y., Gao, B."Angiotensin-(1-7) inhibits the migration and invasion of A549 human lung adenocarcinoma cells through inactivation of the PI3K/Akt and MAPK signaling pathways". Oncology Reports 27.3 (2012): 783-790.
Chicago
Ni, L., Feng, Y., Wan, H., Ma, Q., Fan, L., Qian, Y., Li, Q., Xiang, Y., Gao, B."Angiotensin-(1-7) inhibits the migration and invasion of A549 human lung adenocarcinoma cells through inactivation of the PI3K/Akt and MAPK signaling pathways". Oncology Reports 27, no. 3 (2012): 783-790. https://doi.org/10.3892/or.2011.1554
Copy and paste a formatted citation
x
Spandidos Publications style
Ni L, Feng Y, Wan H, Ma Q, Fan L, Qian Y, Li Q, Xiang Y and Gao B: Angiotensin-(1-7) inhibits the migration and invasion of A549 human lung adenocarcinoma cells through inactivation of the PI3K/Akt and MAPK signaling pathways. Oncol Rep 27: 783-790, 2012.
APA
Ni, L., Feng, Y., Wan, H., Ma, Q., Fan, L., Qian, Y. ... Gao, B. (2012). Angiotensin-(1-7) inhibits the migration and invasion of A549 human lung adenocarcinoma cells through inactivation of the PI3K/Akt and MAPK signaling pathways. Oncology Reports, 27, 783-790. https://doi.org/10.3892/or.2011.1554
MLA
Ni, L., Feng, Y., Wan, H., Ma, Q., Fan, L., Qian, Y., Li, Q., Xiang, Y., Gao, B."Angiotensin-(1-7) inhibits the migration and invasion of A549 human lung adenocarcinoma cells through inactivation of the PI3K/Akt and MAPK signaling pathways". Oncology Reports 27.3 (2012): 783-790.
Chicago
Ni, L., Feng, Y., Wan, H., Ma, Q., Fan, L., Qian, Y., Li, Q., Xiang, Y., Gao, B."Angiotensin-(1-7) inhibits the migration and invasion of A549 human lung adenocarcinoma cells through inactivation of the PI3K/Akt and MAPK signaling pathways". Oncology Reports 27, no. 3 (2012): 783-790. https://doi.org/10.3892/or.2011.1554
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