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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2012 Volume 28 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Lentivirus-mediated RNA interference targeting WWTR1 in human colorectal cancer cells inhibits cell proliferation in vitro and tumor growth in vivo

  • Authors:
    • Jie Pan
    • Shaotang Li
    • Pan Chi
    • Zongbin Xu
    • Xingrong Lu
    • Ying Huang

  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian, P.R. China
  • Pages: 179-185
    |
    Published online on: April 2, 2012
       https://doi.org/10.3892/or.2012.1751
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Abstract

WW domain-containing transcription regulator 1 (WWTR1) was initially identified as a transcriptional coactivator involved in the differentiation of stem cells as well as the development of multiple organs. Recently, WWTR1 has also been identified as a major component of the novel Hippo signalling pathway important for the development of breast and lung cancer. Here, we show for the first time that WWTR1 has an oncogenic function in colorectal cancer cell lines. Knockdown of WWTR1 by lentivirus-mediated RNA interference in human colorectal cancer cells significantly decreased cell prolifer­ation and the colony formation of RKO cells in vitro and tumor growth in vivo. Furthermore, we found that the decreased proliferation was due to cell cycle arrest and increased apoptosis. In addition, efficient knockdown of WWTR1, demonstrated by quantitative real-time PCR, led to upregulation of ASNS and downregulation of SMAD3, LTBR, BAX and BAK1 in WWTR1 knockdown cells, suggesting that these genes may be involved in the repression of cell proliferation. Our findings indicate that WWTR1 is an oncogene and has an important role in the proliferation of colorectal cancer cells and in tumor growth in vivo.

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Copy and paste a formatted citation
Spandidos Publications style
Pan J, Li S, Chi P, Xu Z, Lu X and Huang Y: Lentivirus-mediated RNA interference targeting WWTR1 in human colorectal cancer cells inhibits cell proliferation in vitro and tumor growth in vivo. Oncol Rep 28: 179-185, 2012.
APA
Pan, J., Li, S., Chi, P., Xu, Z., Lu, X., & Huang, Y. (2012). Lentivirus-mediated RNA interference targeting WWTR1 in human colorectal cancer cells inhibits cell proliferation in vitro and tumor growth in vivo. Oncology Reports, 28, 179-185. https://doi.org/10.3892/or.2012.1751
MLA
Pan, J., Li, S., Chi, P., Xu, Z., Lu, X., Huang, Y."Lentivirus-mediated RNA interference targeting WWTR1 in human colorectal cancer cells inhibits cell proliferation in vitro and tumor growth in vivo". Oncology Reports 28.1 (2012): 179-185.
Chicago
Pan, J., Li, S., Chi, P., Xu, Z., Lu, X., Huang, Y."Lentivirus-mediated RNA interference targeting WWTR1 in human colorectal cancer cells inhibits cell proliferation in vitro and tumor growth in vivo". Oncology Reports 28, no. 1 (2012): 179-185. https://doi.org/10.3892/or.2012.1751
Copy and paste a formatted citation
x
Spandidos Publications style
Pan J, Li S, Chi P, Xu Z, Lu X and Huang Y: Lentivirus-mediated RNA interference targeting WWTR1 in human colorectal cancer cells inhibits cell proliferation in vitro and tumor growth in vivo. Oncol Rep 28: 179-185, 2012.
APA
Pan, J., Li, S., Chi, P., Xu, Z., Lu, X., & Huang, Y. (2012). Lentivirus-mediated RNA interference targeting WWTR1 in human colorectal cancer cells inhibits cell proliferation in vitro and tumor growth in vivo. Oncology Reports, 28, 179-185. https://doi.org/10.3892/or.2012.1751
MLA
Pan, J., Li, S., Chi, P., Xu, Z., Lu, X., Huang, Y."Lentivirus-mediated RNA interference targeting WWTR1 in human colorectal cancer cells inhibits cell proliferation in vitro and tumor growth in vivo". Oncology Reports 28.1 (2012): 179-185.
Chicago
Pan, J., Li, S., Chi, P., Xu, Z., Lu, X., Huang, Y."Lentivirus-mediated RNA interference targeting WWTR1 in human colorectal cancer cells inhibits cell proliferation in vitro and tumor growth in vivo". Oncology Reports 28, no. 1 (2012): 179-185. https://doi.org/10.3892/or.2012.1751
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