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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2012 Volume 28 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2012 Volume 28 Issue 1

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Article

Effects of a human compact anti-ErbB2 antibody on prostate cancer

  • Authors:
    • Angela Eliana Malara
    • Carmine Fedele
    • Luigi Aloj
    • Claudio Arra
    • Paolo Laccetti
    • Giuseppe D'Alessio
    • Claudia De Lorenzo

  • View Affiliations / Copyright

    Affiliations: Department of Structural and Functional Biology, University of Naples Federico II, I-80126 Naples, Italy, Department of Nuclear Medicine, IRCCS National Cancer Institute, G. Pascale Foundation, I-80131 Naples, Italy, SSD Animal Facility, IRCCS National Cancer Institute, G. Pascale Foundation, I-80131 Naples, Italy
  • Pages: 297-302
    |
    Published online on: April 10, 2012
       https://doi.org/10.3892/or.2012.1760
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Abstract

Prostate cancer is the most commonly diagnosed malignancy in men in developed countries. ErbB2, a tyrosine kinase receptor overexpressed in many human cancer types, contributes to prostate cancer progression by activating the androgen receptor in a steroid poor environment, thus promoting androgen-independent cell growth. The consequent development of hormone refractory tumors is a major obstacle in prostate cancer therapy. The inhibition of ErbB2 signal transduction pathways by the use of human antibodies could be a valuable alternative strategy for cancer therapy. We performed a comparative analysis in vitro and in vivo of the antitumor effects of three different antibodies targeting different epitopes of ErbB2: Herceptin (trastuzumab), 2C4 (pertuzumab) and Erb-hcAb (human anti-ErbB2-compact antibody), a novel fully human compact antibody produced in our laboratory. Herein, we demonstrate that the growth of both androgen-dependent and independent prostate cancer cells was efficiently inhibited by Erb-hcAb. The antitumor effects induced by Erb-hcAb on some cell lines were more potent than those observed for either Herceptin or 2C4. Thus, Erb-hcAb could be a promising candidate in the immunotherapy of prostate cancer for which no obvious treatment has been reported so far.

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Copy and paste a formatted citation
Spandidos Publications style
Malara AE, Fedele C, Aloj L, Arra C, Laccetti P, D'Alessio G and De Lorenzo C: Effects of a human compact anti-ErbB2 antibody on prostate cancer. Oncol Rep 28: 297-302, 2012.
APA
Malara, A.E., Fedele, C., Aloj, L., Arra, C., Laccetti, P., D'Alessio, G., & De Lorenzo, C. (2012). Effects of a human compact anti-ErbB2 antibody on prostate cancer. Oncology Reports, 28, 297-302. https://doi.org/10.3892/or.2012.1760
MLA
Malara, A. E., Fedele, C., Aloj, L., Arra, C., Laccetti, P., D'Alessio, G., De Lorenzo, C."Effects of a human compact anti-ErbB2 antibody on prostate cancer". Oncology Reports 28.1 (2012): 297-302.
Chicago
Malara, A. E., Fedele, C., Aloj, L., Arra, C., Laccetti, P., D'Alessio, G., De Lorenzo, C."Effects of a human compact anti-ErbB2 antibody on prostate cancer". Oncology Reports 28, no. 1 (2012): 297-302. https://doi.org/10.3892/or.2012.1760
Copy and paste a formatted citation
x
Spandidos Publications style
Malara AE, Fedele C, Aloj L, Arra C, Laccetti P, D'Alessio G and De Lorenzo C: Effects of a human compact anti-ErbB2 antibody on prostate cancer. Oncol Rep 28: 297-302, 2012.
APA
Malara, A.E., Fedele, C., Aloj, L., Arra, C., Laccetti, P., D'Alessio, G., & De Lorenzo, C. (2012). Effects of a human compact anti-ErbB2 antibody on prostate cancer. Oncology Reports, 28, 297-302. https://doi.org/10.3892/or.2012.1760
MLA
Malara, A. E., Fedele, C., Aloj, L., Arra, C., Laccetti, P., D'Alessio, G., De Lorenzo, C."Effects of a human compact anti-ErbB2 antibody on prostate cancer". Oncology Reports 28.1 (2012): 297-302.
Chicago
Malara, A. E., Fedele, C., Aloj, L., Arra, C., Laccetti, P., D'Alessio, G., De Lorenzo, C."Effects of a human compact anti-ErbB2 antibody on prostate cancer". Oncology Reports 28, no. 1 (2012): 297-302. https://doi.org/10.3892/or.2012.1760
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