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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2012 Volume 28 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2012 Volume 28 Issue 1

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Article

MTA1 gene silencing inhibits invasion and alters the microRNA expression profile of human lung cancer cells

  • Authors:
    • Xiaoxia Zhu
    • Xiao Zhang
    • Haofei Wang
    • Qingcui Song
    • Gong Zhang
    • Lei Yang
    • Jian Geng
    • Xiangzhao Li
    • Yawei Yuan
    • Longhua Chen

  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Cardiothoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Cancer Research Institute, Key Laboratory for Transcriptomics and Proteomics of Human Fatal Diseases, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
  • Pages: 218-224
    |
    Published online on: April 20, 2012
       https://doi.org/10.3892/or.2012.1770
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Abstract

Metastasis-associated gene 1 (MTA1) is involved in the carcinogenesis and metastasis of many human carcinomas. However, its exact role in non-small cell lung cancer (NSCLC) is still unclear. Using immunohistochemistry analysis, we recently identified MTA1 to be associated with the progression of NSCLC. Here, we carried out further analysis on the effect of MTA1 knockdown in an NSCLC cell line on cell functions and the global microRNA (miRNA) expression profile. We succeeded in establishing the MTA1 knockdown NSCLC cell line using RNA interference (RNAi), and found that the silencing of MTA1 resulted in the effective inhibition of the invasive ability of NSCLC cells, but not of the cell growth in vitro. We performed an miRNA microarray analysis and demonstrated for the first time that MTA1 knockdown significantly changed the expression of some miRNAs in NSCLC cells. Among them, some have a well-characterized association with cancer progression, e.g. miR-125b, miR-210, miR-103, miR-194 and miR-500. In summary, it is evident from our results that MTA1 functions in regulating the invasive phenotype of lung cancer cells and this regulation may be through altered miRNA expression. The interaction between MTA1 and the miRNAs which contributes to lung cancer is worthy of further investigation.

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Copy and paste a formatted citation
Spandidos Publications style
Zhu X, Zhang X, Wang H, Song Q, Zhang G, Yang L, Geng J, Li X, Yuan Y, Chen L, Chen L, et al: MTA1 gene silencing inhibits invasion and alters the microRNA expression profile of human lung cancer cells. Oncol Rep 28: 218-224, 2012.
APA
Zhu, X., Zhang, X., Wang, H., Song, Q., Zhang, G., Yang, L. ... Chen, L. (2012). MTA1 gene silencing inhibits invasion and alters the microRNA expression profile of human lung cancer cells. Oncology Reports, 28, 218-224. https://doi.org/10.3892/or.2012.1770
MLA
Zhu, X., Zhang, X., Wang, H., Song, Q., Zhang, G., Yang, L., Geng, J., Li, X., Yuan, Y., Chen, L."MTA1 gene silencing inhibits invasion and alters the microRNA expression profile of human lung cancer cells". Oncology Reports 28.1 (2012): 218-224.
Chicago
Zhu, X., Zhang, X., Wang, H., Song, Q., Zhang, G., Yang, L., Geng, J., Li, X., Yuan, Y., Chen, L."MTA1 gene silencing inhibits invasion and alters the microRNA expression profile of human lung cancer cells". Oncology Reports 28, no. 1 (2012): 218-224. https://doi.org/10.3892/or.2012.1770
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu X, Zhang X, Wang H, Song Q, Zhang G, Yang L, Geng J, Li X, Yuan Y, Chen L, Chen L, et al: MTA1 gene silencing inhibits invasion and alters the microRNA expression profile of human lung cancer cells. Oncol Rep 28: 218-224, 2012.
APA
Zhu, X., Zhang, X., Wang, H., Song, Q., Zhang, G., Yang, L. ... Chen, L. (2012). MTA1 gene silencing inhibits invasion and alters the microRNA expression profile of human lung cancer cells. Oncology Reports, 28, 218-224. https://doi.org/10.3892/or.2012.1770
MLA
Zhu, X., Zhang, X., Wang, H., Song, Q., Zhang, G., Yang, L., Geng, J., Li, X., Yuan, Y., Chen, L."MTA1 gene silencing inhibits invasion and alters the microRNA expression profile of human lung cancer cells". Oncology Reports 28.1 (2012): 218-224.
Chicago
Zhu, X., Zhang, X., Wang, H., Song, Q., Zhang, G., Yang, L., Geng, J., Li, X., Yuan, Y., Chen, L."MTA1 gene silencing inhibits invasion and alters the microRNA expression profile of human lung cancer cells". Oncology Reports 28, no. 1 (2012): 218-224. https://doi.org/10.3892/or.2012.1770
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