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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2012 Volume 28 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP

  • Authors:
    • Shijun Li
    • Guangxia Shi
    • Hong Yuan
    • Tao Zhou
    • Qiuping Zhang
    • Hong Zhu
    • Xiaoyan Wang

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Pathophysiology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Department of Oncology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Pathology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
  • Pages: 133-140
    |
    Published online on: April 23, 2012
       https://doi.org/10.3892/or.2012.1778
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Abstract

The p53 protein is one of the best-known tumor suppressors. Recently discovered ASPP1 and ASPP2 are specific activators and iASPP is an inhibitor of p53. In the present study, we found that of 37 NSCLC patients, p53 alterations were detected in 20 tumors (54.1%), the mRNA expression of ASPP1 and ASPP2 was frequently dowregulated in tumor tissues, and this decreased significantly in samples expressing wild-type p53. The expression of ASPP1 and ASPP2 was downregulated and that of iASPP was upregulated in two NSCLC cell lines (the NCI-H157 cell line with altered p53 and the A549 cell line with wild-type p53). The NCI-H157 cell with higher ASPP1 and ASPP2 levels was more sensitive to cisplatin than the A549 cells with lower ASPP1 and ASPP2 levels. Downregulation of iASPP by siRNA stimulated apoptosis through p53 in two NSCLC cell lines. These findings provide new insights into the molecular mechanisms of action of the ASPP family in NSCLC and may have potent therapeutic applications.

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Copy and paste a formatted citation
Spandidos Publications style
Li S, Shi G, Yuan H, Zhou T, Zhang Q, Zhu H and Wang X: Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP. Oncol Rep 28: 133-140, 2012.
APA
Li, S., Shi, G., Yuan, H., Zhou, T., Zhang, Q., Zhu, H., & Wang, X. (2012). Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP. Oncology Reports, 28, 133-140. https://doi.org/10.3892/or.2012.1778
MLA
Li, S., Shi, G., Yuan, H., Zhou, T., Zhang, Q., Zhu, H., Wang, X."Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP". Oncology Reports 28.1 (2012): 133-140.
Chicago
Li, S., Shi, G., Yuan, H., Zhou, T., Zhang, Q., Zhu, H., Wang, X."Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP". Oncology Reports 28, no. 1 (2012): 133-140. https://doi.org/10.3892/or.2012.1778
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Shi G, Yuan H, Zhou T, Zhang Q, Zhu H and Wang X: Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP. Oncol Rep 28: 133-140, 2012.
APA
Li, S., Shi, G., Yuan, H., Zhou, T., Zhang, Q., Zhu, H., & Wang, X. (2012). Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP. Oncology Reports, 28, 133-140. https://doi.org/10.3892/or.2012.1778
MLA
Li, S., Shi, G., Yuan, H., Zhou, T., Zhang, Q., Zhu, H., Wang, X."Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP". Oncology Reports 28.1 (2012): 133-140.
Chicago
Li, S., Shi, G., Yuan, H., Zhou, T., Zhang, Q., Zhu, H., Wang, X."Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP". Oncology Reports 28, no. 1 (2012): 133-140. https://doi.org/10.3892/or.2012.1778
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