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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2012 Volume 28 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article Open Access

Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells

  • Authors:
    • Bo Li
    • Shuohui Gao
    • Feng Wei
    • Anita C. Bellail
    • Chunhai Hao
    • Tongjun Liu

  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, The Third Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Pathology and Laboratory Medicine, Emory University School Medicine, Atlanta, GA 30329, USA
  • Pages: 15-20
    |
    Published online on: April 26, 2012
       https://doi.org/10.3892/or.2012.1786
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Abstract

Epidermal growth factor receptor (EGFR) is highly expressed in colorectal carcinomas and, as a result, it leads to the activation of downstream mammalian target of rapamycin (mTOR) kinase pathways for cancer growth and progression. Clinical and preclinical studies, however, have shown that inhibition of epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) alone is not sufficient to treat colorectal carcinomas. In search of effective combination therapies, we show here that simultaneous targeting of EGFR with its inhibitor, erlotinib and mTOR with its inhibitor, rapamycin inhibits the phosphorylation and activation of downstream phosphatidylinositol 3-kinase (PI3K), Akt, mTOR and extracellular-signal-regulated kinase 1/2 (Erk1/2) pathways, resulting in the inhibition of cell cycle progression and the growth of both KRAS wild-type and mutated colorectal carcinoma cells. This study has demonstrated the principle that the combination of erlotinib and rapamycin may provide an effective therapy for colorectal carcinomas.

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Copy and paste a formatted citation
Spandidos Publications style
Li B, Gao S, Wei F, Bellail AC, Hao C and Liu T: Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells. Oncol Rep 28: 15-20, 2012.
APA
Li, B., Gao, S., Wei, F., Bellail, A.C., Hao, C., & Liu, T. (2012). Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells. Oncology Reports, 28, 15-20. https://doi.org/10.3892/or.2012.1786
MLA
Li, B., Gao, S., Wei, F., Bellail, A. C., Hao, C., Liu, T."Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells". Oncology Reports 28.1 (2012): 15-20.
Chicago
Li, B., Gao, S., Wei, F., Bellail, A. C., Hao, C., Liu, T."Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells". Oncology Reports 28, no. 1 (2012): 15-20. https://doi.org/10.3892/or.2012.1786
Copy and paste a formatted citation
x
Spandidos Publications style
Li B, Gao S, Wei F, Bellail AC, Hao C and Liu T: Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells. Oncol Rep 28: 15-20, 2012.
APA
Li, B., Gao, S., Wei, F., Bellail, A.C., Hao, C., & Liu, T. (2012). Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells. Oncology Reports, 28, 15-20. https://doi.org/10.3892/or.2012.1786
MLA
Li, B., Gao, S., Wei, F., Bellail, A. C., Hao, C., Liu, T."Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells". Oncology Reports 28.1 (2012): 15-20.
Chicago
Li, B., Gao, S., Wei, F., Bellail, A. C., Hao, C., Liu, T."Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells". Oncology Reports 28, no. 1 (2012): 15-20. https://doi.org/10.3892/or.2012.1786
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