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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2012 Volume 28 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Location and the functionality of erythropoietin receptor(s) in A2780 cells

  • Authors:
    • Peter Solár
    • Gabriela Hrčková
    • Lenka Varinská
    • Zuzana Solárová
    • Ján Kriška
    • Ivana Uhrínová
    • Martin Kello
    • Ján Mojžiš
    • Peter Fedoročko
    • Arthur J. Sytkowski

  • View Affiliations / Copyright

    Affiliations: Laboratory for Cell Biology, Institute of Biology and Ecology, Faculty of Science, P.J. Šafárik University, 040 01 Košice, Slovak Republic, Institute of Parasitology, Slovak Academy of Sciences, 040 01 Košice, Slovak Republic, Department of Pharmacology, P.J. Šafárik University, 040 01 Košice, Slovak Republic, Geriatric Nursing Clinic, Faculty of Medicine, P.J. Šafárik University, 040 01 Košice, Slovak Republic, Laboratory for Cell and Molecular Biology, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
  • Pages: 141-146
    |
    Published online on: April 30, 2012
       https://doi.org/10.3892/or.2012.1795
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Abstract

Erythropoietin (Epo) is a critical regulator of erythroid cell proliferation, differentiation and apoptosis. In the form of a recombinant protein, it is widely used to treat various forms of anemia, including that associated with cancer and with the myelosuppressive effects of chemotherapy. Studies of ovarian cancer cell lines have demonstrated the presence of the Epo receptor (EpoR), but there are disagreements regarding its localization and functionality in these cells. Using fluorescence microscopy, we were not able to identify the EpoR on the surface of A2780 cells, in contrast to the positive control K562 cells. Flow cytometry did reveal a weak surface EpoR signal in A2780 cells. Interestingly, most of the EpoR in A2780 cells was found in the cytoplasm, more abundantly as an intracellular membrane-associated protein than a soluble one. Silencing EpoR expression by lentiviral-mediated shRNA resulted in reduced A2780 prolife-ration as well as reduction in Epo-induced phosphorylation of Erk1/2. Our findings provide important insights into the biology of the EpoR in ovarian cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Solár P, Hrčková G, Varinská L, Solárová Z, Kriška J, Uhrínová I, Kello M, Mojžiš J, Fedoročko P, Sytkowski A , Sytkowski A , et al: Location and the functionality of erythropoietin receptor(s) in A2780 cells. Oncol Rep 28: 141-146, 2012.
APA
Solár, P., Hrčková, G., Varinská, L., Solárová, Z., Kriška, J., Uhrínová, I. ... Sytkowski, A. . (2012). Location and the functionality of erythropoietin receptor(s) in A2780 cells. Oncology Reports, 28, 141-146. https://doi.org/10.3892/or.2012.1795
MLA
Solár, P., Hrčková, G., Varinská, L., Solárová, Z., Kriška, J., Uhrínová, I., Kello, M., Mojžiš, J., Fedoročko, P., Sytkowski, A. ."Location and the functionality of erythropoietin receptor(s) in A2780 cells". Oncology Reports 28.1 (2012): 141-146.
Chicago
Solár, P., Hrčková, G., Varinská, L., Solárová, Z., Kriška, J., Uhrínová, I., Kello, M., Mojžiš, J., Fedoročko, P., Sytkowski, A. ."Location and the functionality of erythropoietin receptor(s) in A2780 cells". Oncology Reports 28, no. 1 (2012): 141-146. https://doi.org/10.3892/or.2012.1795
Copy and paste a formatted citation
x
Spandidos Publications style
Solár P, Hrčková G, Varinská L, Solárová Z, Kriška J, Uhrínová I, Kello M, Mojžiš J, Fedoročko P, Sytkowski A , Sytkowski A , et al: Location and the functionality of erythropoietin receptor(s) in A2780 cells. Oncol Rep 28: 141-146, 2012.
APA
Solár, P., Hrčková, G., Varinská, L., Solárová, Z., Kriška, J., Uhrínová, I. ... Sytkowski, A. . (2012). Location and the functionality of erythropoietin receptor(s) in A2780 cells. Oncology Reports, 28, 141-146. https://doi.org/10.3892/or.2012.1795
MLA
Solár, P., Hrčková, G., Varinská, L., Solárová, Z., Kriška, J., Uhrínová, I., Kello, M., Mojžiš, J., Fedoročko, P., Sytkowski, A. ."Location and the functionality of erythropoietin receptor(s) in A2780 cells". Oncology Reports 28.1 (2012): 141-146.
Chicago
Solár, P., Hrčková, G., Varinská, L., Solárová, Z., Kriška, J., Uhrínová, I., Kello, M., Mojžiš, J., Fedoročko, P., Sytkowski, A. ."Location and the functionality of erythropoietin receptor(s) in A2780 cells". Oncology Reports 28, no. 1 (2012): 141-146. https://doi.org/10.3892/or.2012.1795
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