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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2012 Volume 28 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2012 Volume 28 Issue 1

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Article

Effects of SEMA3G on migration and invasion of glioma cells

  • Authors:
    • Xiuping Zhou
    • Lin Ma
    • Jian Li
    • Jia Gu
    • Qiong Shi
    • Rutong Yu

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, P.R. China, The Graduate School, Xuzhou Medical College, Xuzhou, Jiangsu, P.R. China
  • Pages: 269-275
    |
    Published online on: May 4, 2012
       https://doi.org/10.3892/or.2012.1796
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Abstract

Glioblastoma multiforme is the most aggressive type of brain tumor with a strong ability to invade and migrate into surrounding normal brain tissues, leading to high tumor recurrence and mortality. Most of class-3 semaphorins, especially SEMA3A, SEMA3B and SEMA3F, have been reported to have strong tumor inhibition ability, but the role of SEMA3G in tumor biology is largely unknown. We report here that SEMA3G possesses anti-migration and anti-invasion ability. To determine the potential effects of SEMA3G on migratory and invasive ability, we generated stable SEMA3G expression U251MG cells. We found that stably overexpressed SEMA3G inhibited the migratory and invasive behavior of U251MG cells. In addition, treatment with SEMA3G conditioned media also decreased the migratory and invasive ability of parental U251MG cells. Furthermore, SEMA3G also inhibited the activity of MMP2, an index of tumor invasion ability. Thus, our results suggest that SEMA3G inhibited tumor cell migration and invasion, which may be obtained through cell autonomous or paracrine mechanisms, and SEMA3G is a potential target for antitumor migration and invasion.

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Copy and paste a formatted citation
Spandidos Publications style
Zhou X, Ma L, Li J, Gu J, Shi Q and Yu R: Effects of SEMA3G on migration and invasion of glioma cells. Oncol Rep 28: 269-275, 2012.
APA
Zhou, X., Ma, L., Li, J., Gu, J., Shi, Q., & Yu, R. (2012). Effects of SEMA3G on migration and invasion of glioma cells. Oncology Reports, 28, 269-275. https://doi.org/10.3892/or.2012.1796
MLA
Zhou, X., Ma, L., Li, J., Gu, J., Shi, Q., Yu, R."Effects of SEMA3G on migration and invasion of glioma cells". Oncology Reports 28.1 (2012): 269-275.
Chicago
Zhou, X., Ma, L., Li, J., Gu, J., Shi, Q., Yu, R."Effects of SEMA3G on migration and invasion of glioma cells". Oncology Reports 28, no. 1 (2012): 269-275. https://doi.org/10.3892/or.2012.1796
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Ma L, Li J, Gu J, Shi Q and Yu R: Effects of SEMA3G on migration and invasion of glioma cells. Oncol Rep 28: 269-275, 2012.
APA
Zhou, X., Ma, L., Li, J., Gu, J., Shi, Q., & Yu, R. (2012). Effects of SEMA3G on migration and invasion of glioma cells. Oncology Reports, 28, 269-275. https://doi.org/10.3892/or.2012.1796
MLA
Zhou, X., Ma, L., Li, J., Gu, J., Shi, Q., Yu, R."Effects of SEMA3G on migration and invasion of glioma cells". Oncology Reports 28.1 (2012): 269-275.
Chicago
Zhou, X., Ma, L., Li, J., Gu, J., Shi, Q., Yu, R."Effects of SEMA3G on migration and invasion of glioma cells". Oncology Reports 28, no. 1 (2012): 269-275. https://doi.org/10.3892/or.2012.1796
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