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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April-2026 Volume 55 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article Open Access

Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells

  • Authors:
    • Wentao Fu
    • Leying Lin
    • Jie Li
    • Fei Qin
    • Chuan Chen
    • Yinglian Cai
    • Yilun Cai
    • Yiling Huang
    • Wang Yang
    • Shanshan Zhu

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Xiamen Medical College, Xiamen, Fujian 361023, P.R. China, Department of Pharmacy, Innovation Research Center for Biological Enzyme Catalysis and Drug Synthesis, Xiamen Medical College, Xiamen, Fujian 361023, P.R. China, Department of Pharmacy, Xiamen Traditional Chinese Medicine Hospital, Xiamen, Fujian 361006, P.R. China
    Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 63
    |
    Published online on: February 2, 2026
       https://doi.org/10.3892/or.2026.9068
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Abstract

Breast cancer is a global health challenge for women and chemoresistance is a major contributor to its high mortality rates. Quercetin (Que), a flavonoid with antioxidant, antiviral, anti‑tumor and anti‑inflammatory properties, sensitizes cancer cells to chemotherapy. The present study investigated the mechanism by which Que regulates ATP‑binding cassette (ABC) transporter expression in MCF‑7 cells using a PTEN overexpression plasmid and the PI3K inhibitor LY294002. The present study assessed cell viability via Cell Counting Kit‑8 and Hoechst 33342 staining and analyzed mRNA and protein expression levels by reverse transcription‑quantitative PCR and western blotting. Apoptosis was evaluated by flow cytometry and ABCG2 expression was detected by immunofluorescence. Furthermore, the present study determined the effect of Que on drug uptake using a Rhodamine 123 accumulation assay. The results of the present study demonstrated that Que suppresses cell viability and induces apoptosis in MCF‑7 cells. Moreover, it enhances intracellular drug accumulation and downregulates ABC transporter expression by modulating the PTEN/PI3K/AKT signaling pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Fu W, Lin L, Li J, Qin F, Chen C, Cai Y, Cai Y, Huang Y, Yang W, Zhu S, Zhu S, et al: <p>Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells</p>. Oncol Rep 55: 63, 2026.
APA
Fu, W., Lin, L., Li, J., Qin, F., Chen, C., Cai, Y. ... Zhu, S. (2026). <p>Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells</p>. Oncology Reports, 55, 63. https://doi.org/10.3892/or.2026.9068
MLA
Fu, W., Lin, L., Li, J., Qin, F., Chen, C., Cai, Y., Cai, Y., Huang, Y., Yang, W., Zhu, S."<p>Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells</p>". Oncology Reports 55.4 (2026): 63.
Chicago
Fu, W., Lin, L., Li, J., Qin, F., Chen, C., Cai, Y., Cai, Y., Huang, Y., Yang, W., Zhu, S."<p>Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells</p>". Oncology Reports 55, no. 4 (2026): 63. https://doi.org/10.3892/or.2026.9068
Copy and paste a formatted citation
x
Spandidos Publications style
Fu W, Lin L, Li J, Qin F, Chen C, Cai Y, Cai Y, Huang Y, Yang W, Zhu S, Zhu S, et al: <p>Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells</p>. Oncol Rep 55: 63, 2026.
APA
Fu, W., Lin, L., Li, J., Qin, F., Chen, C., Cai, Y. ... Zhu, S. (2026). <p>Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells</p>. Oncology Reports, 55, 63. https://doi.org/10.3892/or.2026.9068
MLA
Fu, W., Lin, L., Li, J., Qin, F., Chen, C., Cai, Y., Cai, Y., Huang, Y., Yang, W., Zhu, S."<p>Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells</p>". Oncology Reports 55.4 (2026): 63.
Chicago
Fu, W., Lin, L., Li, J., Qin, F., Chen, C., Cai, Y., Cai, Y., Huang, Y., Yang, W., Zhu, S."<p>Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells</p>". Oncology Reports 55, no. 4 (2026): 63. https://doi.org/10.3892/or.2026.9068
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