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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June-2026 Volume 55 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article Open Access

Mechanistic study of MUC3A in promoting progression of clear cell renal cell carcinoma via the JAK‑STAT pathway

  • Authors:
    • Yongyang Yun
    • Xing Ji
    • Shuai Hu
    • Tianyu Wu
    • Yixiao Liu
    • Zheng Li
    • Zhoujie Sun
    • Peimin Zhou
    • Lei Yang
    • Wei Yu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Peking University First Hospital, Beijing 100034, P.R. China
    Copyright: © Yun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 114
    |
    Published online on: April 14, 2026
       https://doi.org/10.3892/or.2026.9119
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Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer and is associated with poor prognosis. The present study identified a membrane‑associated mucin, mucin 3A (MUC3A), a transmembrane glycoprotein, as a novel oncogenic factor in ccRCC. MUC3A was found to be highly expressed in ccRCC tissues and cell lines, with elevated levels associated with worse patient survival. Functional assays demonstrated that MUC3A knockdown significantly inhibited cell proliferation, migration, invasion, and promoted apoptosis. Mechanistically, MUC3A activated the Janus kinase‑signal transducer and activator of transcription (JAK‑STAT) signaling pathway, and activation of STAT3 reversed the effects of MUC3A knockdown. These findings suggest that MUC3A facilitates ccRCC progression via JAK/STAT signaling and may serve as a potential prognostic biomarker and therapeutic target.

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Copy and paste a formatted citation
Spandidos Publications style
Yun Y, Ji X, Hu S, Wu T, Liu Y, Li Z, Sun Z, Zhou P, Yang L, Yu W, Yu W, et al: Mechanistic study of MUC3A in promoting progression of clear cell renal cell carcinoma via the JAK‑STAT pathway. Oncol Rep 55: 114, 2026.
APA
Yun, Y., Ji, X., Hu, S., Wu, T., Liu, Y., Li, Z. ... Yu, W. (2026). Mechanistic study of MUC3A in promoting progression of clear cell renal cell carcinoma via the JAK‑STAT pathway. Oncology Reports, 55, 114. https://doi.org/10.3892/or.2026.9119
MLA
Yun, Y., Ji, X., Hu, S., Wu, T., Liu, Y., Li, Z., Sun, Z., Zhou, P., Yang, L., Yu, W."Mechanistic study of MUC3A in promoting progression of clear cell renal cell carcinoma via the JAK‑STAT pathway". Oncology Reports 55.6 (2026): 114.
Chicago
Yun, Y., Ji, X., Hu, S., Wu, T., Liu, Y., Li, Z., Sun, Z., Zhou, P., Yang, L., Yu, W."Mechanistic study of MUC3A in promoting progression of clear cell renal cell carcinoma via the JAK‑STAT pathway". Oncology Reports 55, no. 6 (2026): 114. https://doi.org/10.3892/or.2026.9119
Copy and paste a formatted citation
x
Spandidos Publications style
Yun Y, Ji X, Hu S, Wu T, Liu Y, Li Z, Sun Z, Zhou P, Yang L, Yu W, Yu W, et al: Mechanistic study of MUC3A in promoting progression of clear cell renal cell carcinoma via the JAK‑STAT pathway. Oncol Rep 55: 114, 2026.
APA
Yun, Y., Ji, X., Hu, S., Wu, T., Liu, Y., Li, Z. ... Yu, W. (2026). Mechanistic study of MUC3A in promoting progression of clear cell renal cell carcinoma via the JAK‑STAT pathway. Oncology Reports, 55, 114. https://doi.org/10.3892/or.2026.9119
MLA
Yun, Y., Ji, X., Hu, S., Wu, T., Liu, Y., Li, Z., Sun, Z., Zhou, P., Yang, L., Yu, W."Mechanistic study of MUC3A in promoting progression of clear cell renal cell carcinoma via the JAK‑STAT pathway". Oncology Reports 55.6 (2026): 114.
Chicago
Yun, Y., Ji, X., Hu, S., Wu, T., Liu, Y., Li, Z., Sun, Z., Zhou, P., Yang, L., Yu, W."Mechanistic study of MUC3A in promoting progression of clear cell renal cell carcinoma via the JAK‑STAT pathway". Oncology Reports 55, no. 6 (2026): 114. https://doi.org/10.3892/or.2026.9119
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