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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August-2026 Volume 56 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Review

Research advances on DKK1 in head and neck squamous cell carcinoma: Linking molecular mechanisms to clinical applications (Review)

  • Authors:
    • Xiaoqian Zhu
    • Liwei Hong
    • Weihan Chen
    • Junjuan Tan
    • Juju Zhou
    • Lingya Yang
    • Yonglin Liu
    • Tiantian Zhai
    • Kai Chen

  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 515000, P.R. China, Department of Radiation Oncology, the First People's Hospital of Foshan, Foshan, Guangdong 528000, P.R. China
  • Article Number: 146
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    Published online on: June 16, 2026
       https://doi.org/10.3892/or.2026.9151
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Abstract

Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies worldwide, characterized by persistently high and increasing rates of incidence, recurrence and mortality, thereby posing a considerable global public health challenge. Within the complex molecular network driving the malignant progression of HNSCC, Dickkopf‑1 (DKK1), a classical secreted antagonist of the Wnt signaling pathway, has garnered considerable attention due to its pleiotropic roles in tumor initiation, progression and therapeutic resistance. The expression of DKK1 is regulated by a sophisticated network involving both canonical and non‑canonical Wnt pathways, and it exhibits high spatiotemporal specificity and context dependency. The present narrative review discusses the regulatory mechanisms underlying DKK1 expression, its prognostic significance in HNSCC, pro‑tumorigenic molecular mechanisms, immunomodulatory functions and its clinical translational potential as a biomarker and therapeutic target. The present review aims to provide novel insights into the pathogenesis of HNSCC and establish a theoretical foundation for advancing DKK1‑based precision diagnostics and therapeutic strategies.

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Copy and paste a formatted citation
Spandidos Publications style
Zhu X, Hong L, Chen W, Tan J, Zhou J, Yang L, Liu Y, Zhai T and Chen K: Research advances on DKK1 in head and neck squamous cell carcinoma: Linking molecular mechanisms to clinical applications (Review). Oncol Rep 56: 146, 2026.
APA
Zhu, X., Hong, L., Chen, W., Tan, J., Zhou, J., Yang, L. ... Chen, K. (2026). Research advances on DKK1 in head and neck squamous cell carcinoma: Linking molecular mechanisms to clinical applications (Review). Oncology Reports, 56, 146. https://doi.org/10.3892/or.2026.9151
MLA
Zhu, X., Hong, L., Chen, W., Tan, J., Zhou, J., Yang, L., Liu, Y., Zhai, T., Chen, K."Research advances on DKK1 in head and neck squamous cell carcinoma: Linking molecular mechanisms to clinical applications (Review)". Oncology Reports 56.2 (2026): 146.
Chicago
Zhu, X., Hong, L., Chen, W., Tan, J., Zhou, J., Yang, L., Liu, Y., Zhai, T., Chen, K."Research advances on DKK1 in head and neck squamous cell carcinoma: Linking molecular mechanisms to clinical applications (Review)". Oncology Reports 56, no. 2 (2026): 146. https://doi.org/10.3892/or.2026.9151
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu X, Hong L, Chen W, Tan J, Zhou J, Yang L, Liu Y, Zhai T and Chen K: Research advances on DKK1 in head and neck squamous cell carcinoma: Linking molecular mechanisms to clinical applications (Review). Oncol Rep 56: 146, 2026.
APA
Zhu, X., Hong, L., Chen, W., Tan, J., Zhou, J., Yang, L. ... Chen, K. (2026). Research advances on DKK1 in head and neck squamous cell carcinoma: Linking molecular mechanisms to clinical applications (Review). Oncology Reports, 56, 146. https://doi.org/10.3892/or.2026.9151
MLA
Zhu, X., Hong, L., Chen, W., Tan, J., Zhou, J., Yang, L., Liu, Y., Zhai, T., Chen, K."Research advances on DKK1 in head and neck squamous cell carcinoma: Linking molecular mechanisms to clinical applications (Review)". Oncology Reports 56.2 (2026): 146.
Chicago
Zhu, X., Hong, L., Chen, W., Tan, J., Zhou, J., Yang, L., Liu, Y., Zhai, T., Chen, K."Research advances on DKK1 in head and neck squamous cell carcinoma: Linking molecular mechanisms to clinical applications (Review)". Oncology Reports 56, no. 2 (2026): 146. https://doi.org/10.3892/or.2026.9151
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