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The riminophenazine agents clofazimine and B669 inhibit the proliferation of intrinsically multidrug resistant carcinoma cell lines.

  • Authors:
    • C VanRensburg
    • A Theron
    • P Chasen

  • View Affiliations

  • Published online on: January 1, 1996     https://doi.org/10.3892/or.3.1.103
  • Pages: 103-106
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The sensitivity to clofazimine, B669 and eight standard anti-tumour chemotherapeutic agents of four intrinsically multidrug resistant (MDR) cell lines [three human hepatocellular carcinoma cell lines (HepG2, PLC and Mahlavu) and a human colorectal carcinoma cell line (CaCo2)] were compared with that of a human cervix epithelioid carcinoma cell line (HeLa). The MDR cell lines and HeLa cells showed equivalent sensitivity to the riminophenazines, methotrexate and 5-fluorouracil, but exhibited ranging levels of resistance to vinblastine, doxorubicin, mitomycin C, daunorubicin, etoposide and vincristine. Riminophenazines may be useful agents in the chemotherapy of tumours with intrinsic MDR.

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January 1996
Volume 3 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
VanRensburg C, Theron A and Chasen P: The riminophenazine agents clofazimine and B669 inhibit the proliferation of intrinsically multidrug resistant carcinoma cell lines.. Oncol Rep 3: 103-106, 1996
APA
VanRensburg, C., Theron, A., & Chasen, P. (1996). The riminophenazine agents clofazimine and B669 inhibit the proliferation of intrinsically multidrug resistant carcinoma cell lines.. Oncology Reports, 3, 103-106. https://doi.org/10.3892/or.3.1.103
MLA
VanRensburg, C., Theron, A., Chasen, P."The riminophenazine agents clofazimine and B669 inhibit the proliferation of intrinsically multidrug resistant carcinoma cell lines.". Oncology Reports 3.1 (1996): 103-106.
Chicago
VanRensburg, C., Theron, A., Chasen, P."The riminophenazine agents clofazimine and B669 inhibit the proliferation of intrinsically multidrug resistant carcinoma cell lines.". Oncology Reports 3, no. 1 (1996): 103-106. https://doi.org/10.3892/or.3.1.103