Hyaluronic acid modulates glioma cell proliferation through its interaction with CD44H in vitro

  • Authors:
    • S Koochekpour
    • G Pilkington
  • View Affiliations

  • Published online on: January 1, 1996     https://doi.org/10.3892/or.3.1.133
  • Pages: 133-135
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Abstract

In a recent study we showed that hyaluronic acid (HA) induces cell detachment and promotes migration and invasion of glioma cells in vitro through its interaction with the cell surface molecule CD44H. In this study, the role of HA in proliferation in eight human glioma-derived cell Lines was investigated. We demonstrate that HA exerts a dose dependent proliferative and anti-proliferative effect on glioma cells. This effect was found to be partially counteracted by a CD44H monoclonal antibody, suggesting the involvement of its high affinity receptor, CD44H and other HA receptors in this process.

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January 1996
Volume 3 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Koochekpour S and Koochekpour S: Hyaluronic acid modulates glioma cell proliferation through its interaction with CD44H in vitro. Oncol Rep 3: 133-135, 1996
APA
Koochekpour, S., & Koochekpour, S. (1996). Hyaluronic acid modulates glioma cell proliferation through its interaction with CD44H in vitro. Oncology Reports, 3, 133-135. https://doi.org/10.3892/or.3.1.133
MLA
Koochekpour, S., Pilkington, G."Hyaluronic acid modulates glioma cell proliferation through its interaction with CD44H in vitro". Oncology Reports 3.1 (1996): 133-135.
Chicago
Koochekpour, S., Pilkington, G."Hyaluronic acid modulates glioma cell proliferation through its interaction with CD44H in vitro". Oncology Reports 3, no. 1 (1996): 133-135. https://doi.org/10.3892/or.3.1.133