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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 1996 Volume 3 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1996 Volume 3 Issue 1

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Article

Novel mouse repetitive element structures in an embryonal carcinoma mutant cell line

  • Authors:
    • R Gama
    • Y Du
    • J Bauman
    • T Chan
    • P McCormick

  • View Affiliations / Copyright

    Affiliations: SUNY ALBANY,DEPT BIOL SCI,ALBANY,NY 12222.
  • Pages: 171-174
    |
    Published online on: January 1, 1996
       https://doi.org/10.3892/or.3.1.171
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Abstract

A mutant embryonal carcinoma (EC) cell line, NR1-6, has been isolated subsequent to infection with a retroviral insert containing a neomycin resistance cassette (Neo(r)) (1). This variant cell line has only a single insertion site, but is unique in its morphology, tumorigenicity, and differentiative potential (2). In order to understand the exact nature of the mutational event, we have sequenced the regions immediately flanking the insertion site (encompassing over 18 kb). Searches for homology in GenBank using the GCG and Blast programs have revealed homology to only a few small conserved regions (4 B1 repetitive elements approximately 150 bp long and a CA/GT dinucleotide repeat). Interestingly, B1 repetitive elements have been reported to play a role in germ cell differentiation. One of these elements is immediately 5' upstream of the insertion site and it appears as if the retroviral insertion may be responsible for activating or repressing the expression of this element. The CA/GT repeat has not yet been mapped within the mouse genome. Thus, we have identified a novel mouse locus which apparently regulates a number of cellular phenotypes.

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Copy and paste a formatted citation
Spandidos Publications style
Gama R, Du Y, Bauman J, Chan T and McCormick P: Novel mouse repetitive element structures in an embryonal carcinoma mutant cell line. Oncol Rep 3: 171-174, 1996.
APA
Gama, R., Du, Y., Bauman, J., Chan, T., & McCormick, P. (1996). Novel mouse repetitive element structures in an embryonal carcinoma mutant cell line. Oncology Reports, 3, 171-174. https://doi.org/10.3892/or.3.1.171
MLA
Gama, R., Du, Y., Bauman, J., Chan, T., McCormick, P."Novel mouse repetitive element structures in an embryonal carcinoma mutant cell line". Oncology Reports 3.1 (1996): 171-174.
Chicago
Gama, R., Du, Y., Bauman, J., Chan, T., McCormick, P."Novel mouse repetitive element structures in an embryonal carcinoma mutant cell line". Oncology Reports 3, no. 1 (1996): 171-174. https://doi.org/10.3892/or.3.1.171
Copy and paste a formatted citation
x
Spandidos Publications style
Gama R, Du Y, Bauman J, Chan T and McCormick P: Novel mouse repetitive element structures in an embryonal carcinoma mutant cell line. Oncol Rep 3: 171-174, 1996.
APA
Gama, R., Du, Y., Bauman, J., Chan, T., & McCormick, P. (1996). Novel mouse repetitive element structures in an embryonal carcinoma mutant cell line. Oncology Reports, 3, 171-174. https://doi.org/10.3892/or.3.1.171
MLA
Gama, R., Du, Y., Bauman, J., Chan, T., McCormick, P."Novel mouse repetitive element structures in an embryonal carcinoma mutant cell line". Oncology Reports 3.1 (1996): 171-174.
Chicago
Gama, R., Du, Y., Bauman, J., Chan, T., McCormick, P."Novel mouse repetitive element structures in an embryonal carcinoma mutant cell line". Oncology Reports 3, no. 1 (1996): 171-174. https://doi.org/10.3892/or.3.1.171
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