nm23-H1 protein immunohistochemical expression in human breast cancer

Russo,A; Bazan,V; Morello,V; Valli,C; Giarnieri,E; Dardanoni,G; Cucciarre,S; Carreca,I; Bazan,P; Tomasino,R; Vecchione,A

doi:10.3892/or.3.1.183

nm23-H1 protein immunohistochemical expression in human breast cancer

Authors:
- A Russo
- V Bazan
- V Morello
- C Valli
- E Giarnieri
- G Dardanoni
- S Cucciarre
- I Carreca
- P Bazan
- R Tomasino
- A Vecchione
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Affiliations: UNIV PALERMO,POLICLIN P GIACCONE,SCH MED,EXPTL ONCOL SECT,I-90127 PALERMO,ITALY. UNIV PALERMO,POLICLIN P GIACCONE,SCH MED,DEPT CLIN ONCOL RES,DIV GEN SURG,I-90127 PALERMO,ITALY. UNIV PALERMO,POLICLIN P GIACCONE,SCH MED,INST PATHOL R,I-90127 PALERMO,ITALY. UNIV PALERMO,POLICLIN P GIACCONE,SCH MED,INST RADIOL,CYTOPATHOL UNIT,I-90127 PALERMO,ITALY. UNIV ROMA LA SAPIENZA,SCH MED,DEPT EXPTL MED,CYTOPATHOL UNIT,I-00161 ROME,ITALY. EPIDEMIOL OBSERV CTR SICILIAN REG,I-90145 PALERMO,ITALY.
Published online on: January 1, 1996 https://doi.org/10.3892/or.3.1.183
Pages: 183-189

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Abstract

A series of 76 patients undergoing surgery for primary breast carcinoma has been prospectively studied in order to evaluate the relative weight of nm23-H1 protein expression in disease-free survival. Expression of nm23 protein was immunohistochemically assessed. In all, 39% (29/74) of the turners showed positive staining for nm23-H1 protein expression. Negative nm23-H1 expression was found in poorly differentiated, tumors (p<0.02). There was no significant relationship between nm23-H1 and the other clinicopathological and biological features examined. In the univariate statistical analysis, node positivity, G3 histological grade and high flow cytometric S phase fraction (SPF) value proved to be significantly related to risk of relapse. In the multivariate analysis, only histological grade (G3) and high SPF values (>10.6) proved to be independently related to risk of relapse, with a hazard ratio of 9.84 and 7.98 respectively. Our preliminary study suggests that immunohistochemical nm23-H1 expression should not be considered a marker for predicting tumor progression and patient prognosis.