Effects of a new antiulcer agent, ecabet sodium on a cutaneous tumorigenesis induced with 7,12-dimethylbenz(a)anthracene in mice
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- Published online on: March 1, 1996 https://doi.org/10.3892/or.3.2.245
- Pages: 245-247
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Abstract
A new antiulcer agent, ecabet sodium is one of dehydroabietic acid derivatives prepared from pine resin, and is known to have a potent protective effect on gastric hemorrhagic lesions induced with carcinogens by covering a gastric mucosa after oral administration. In the present study, we investigated the effects of synthetic ecabet sodium on cutaneous tumorigenesis and development of skin-tumors induced by 7,12-dimethylbenz(a)anthracene application on mouse back skin. It was tentatively concluded that ecabet sodium reduced the incidence of skin-tumors (squamous cell papillomas) by inhibition of DNA synthesis in de novo pathway, and suppressed the development of papillomas by decrease of DNA synthesis in a salvage pathway.
