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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 1996 Volume 3 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1996 Volume 3 Issue 2

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Article

Efficacy of antiestrogen treatment in a benign metastasizing leiomyoma with paraneoplastic estradiol production

  • Authors:
    • U Ruther
    • C Nunnensiek
    • R Sessler
    • S Stilz
    • T Ulshofer
    • H Muller
    • H Bader
    • C Bokemeyer
    • H Toomes
    • P Jipp

  • View Affiliations / Copyright

    Affiliations: ARZTL PRAXIS,REUTLINGEN,GERMANY. KATHARINEN HOSP,INST PATHOL,D-70174 STUTTGART,GERMANY. KLIN EICHERT,ZENTRUM LAB MED,GOPPONGEN,GERMANY. UNIV TUBINGEN,MED KLIN,W-7400 TUBINGEN,GERMANY. KLIN SCHILLERHOHE,ZENTRUM PNEUMOL & THORAXCHIRURG,GERLINGEN,GERMANY.
  • Pages: 293-299
    |
    Published online on: March 1, 1996
       https://doi.org/10.3892/or.3.2.293
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Abstract

Benign metastasizing leiomyoma (BML) is a rare hormone-dependent disease which occurs predominantly in women during their child-bearing years. After our patient had refused ablative hormone therapy (bilateral ovarectomy), evidence of estrogen and progesteron receptors in tumor tissue taken from the lung sites, as well as extremely high estradiol serum levels, led us to conduct high-dosage antiestrogen therapy for 5 years; daily administration of 250 mg of Tamoxpuren(R) resulted in stable disease of the pulmonary sites without any side effects. This also significantly lowered estradiol serum levels, which improved clinical symptoms. Five years later, the patient's vision suddenly deteriorated due to bilateral macula degeneration. This forced us to stop the antiestrogen therapy and commence alternative treatment with LHRH analogue (3.6 mg Goreselin). We observed stable disease of the pulmonary metastases and low estradiol serum levels during the first 6 months of Goserelin treatment. The response to antiestrogen therapy in BML suggests that the muscular component of these disorders is responsive to estrogen ablation.

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Copy and paste a formatted citation
Spandidos Publications style
Ruther U, Nunnensiek C, Sessler R, Stilz S, Ulshofer T, Muller H, Bader H, Bokemeyer C, Toomes H, Jipp P, Jipp P, et al: Efficacy of antiestrogen treatment in a benign metastasizing leiomyoma with paraneoplastic estradiol production. Oncol Rep 3: 293-299, 1996.
APA
Ruther, U., Nunnensiek, C., Sessler, R., Stilz, S., Ulshofer, T., Muller, H. ... Jipp, P. (1996). Efficacy of antiestrogen treatment in a benign metastasizing leiomyoma with paraneoplastic estradiol production. Oncology Reports, 3, 293-299. https://doi.org/10.3892/or.3.2.293
MLA
Ruther, U., Nunnensiek, C., Sessler, R., Stilz, S., Ulshofer, T., Muller, H., Bader, H., Bokemeyer, C., Toomes, H., Jipp, P."Efficacy of antiestrogen treatment in a benign metastasizing leiomyoma with paraneoplastic estradiol production". Oncology Reports 3.2 (1996): 293-299.
Chicago
Ruther, U., Nunnensiek, C., Sessler, R., Stilz, S., Ulshofer, T., Muller, H., Bader, H., Bokemeyer, C., Toomes, H., Jipp, P."Efficacy of antiestrogen treatment in a benign metastasizing leiomyoma with paraneoplastic estradiol production". Oncology Reports 3, no. 2 (1996): 293-299. https://doi.org/10.3892/or.3.2.293
Copy and paste a formatted citation
x
Spandidos Publications style
Ruther U, Nunnensiek C, Sessler R, Stilz S, Ulshofer T, Muller H, Bader H, Bokemeyer C, Toomes H, Jipp P, Jipp P, et al: Efficacy of antiestrogen treatment in a benign metastasizing leiomyoma with paraneoplastic estradiol production. Oncol Rep 3: 293-299, 1996.
APA
Ruther, U., Nunnensiek, C., Sessler, R., Stilz, S., Ulshofer, T., Muller, H. ... Jipp, P. (1996). Efficacy of antiestrogen treatment in a benign metastasizing leiomyoma with paraneoplastic estradiol production. Oncology Reports, 3, 293-299. https://doi.org/10.3892/or.3.2.293
MLA
Ruther, U., Nunnensiek, C., Sessler, R., Stilz, S., Ulshofer, T., Muller, H., Bader, H., Bokemeyer, C., Toomes, H., Jipp, P."Efficacy of antiestrogen treatment in a benign metastasizing leiomyoma with paraneoplastic estradiol production". Oncology Reports 3.2 (1996): 293-299.
Chicago
Ruther, U., Nunnensiek, C., Sessler, R., Stilz, S., Ulshofer, T., Muller, H., Bader, H., Bokemeyer, C., Toomes, H., Jipp, P."Efficacy of antiestrogen treatment in a benign metastasizing leiomyoma with paraneoplastic estradiol production". Oncology Reports 3, no. 2 (1996): 293-299. https://doi.org/10.3892/or.3.2.293
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