Multiple sites of loss of heterozygosity on chromosome arms 3p and 3q in human breast carcinomas
- Authors:
- Published online on: March 1, 1996 https://doi.org/10.3892/or.3.2.313
- Pages: 313-316
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Abstract
Loss of heterozygosity (LOH) at loci from both arms of chromosome 3 were shown to occur in a high proportion of breast carcinomas. Six regions of consistent loss were identified, and were variably involved in the tumors. This suggests that multiple potential tumor suppressor genes involved in mammary carcinogenesis are present on chromosome 3.