Interferon-gamma enhances TNF sensitivity in A172 human glioblastoma cell line

  • Authors:
    • G Cimoli
    • S Parodi
    • P Russo
  • View Affiliations

  • Published online on: March 1, 1996     https://doi.org/10.3892/or.3.2.369
  • Pages: 369-370
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Abstract

Although human glioblastoma cell line A172 presents tumor necrosis factor (TNF) high affinity receptors, it is resistant to TNF-mediated cytotoxicity. Preincubation of cells with 10 ng/ml interferon (IFN)-gamma for 6 h causes a great increase in TNF receptor numbers (about 477%). IFN-gamma alone is not cytotoxic in A172 cells. Cells preincubated with 10 ng/ml IFN-gamma for 6 h became more sensitive to the TNF cytotoxicity (about 400%). In A172 cells the enhanced TNF receptor expression may contribute to the enhancement of TNF cytotoxicity. This observation may have importance in designing new more effective therapies for human gliomas.

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March 1996
Volume 3 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Cimoli G, Parodi S and Russo P: Interferon-gamma enhances TNF sensitivity in A172 human glioblastoma cell line. Oncol Rep 3: 369-370, 1996
APA
Cimoli, G., Parodi, S., & Russo, P. (1996). Interferon-gamma enhances TNF sensitivity in A172 human glioblastoma cell line. Oncology Reports, 3, 369-370. https://doi.org/10.3892/or.3.2.369
MLA
Cimoli, G., Parodi, S., Russo, P."Interferon-gamma enhances TNF sensitivity in A172 human glioblastoma cell line". Oncology Reports 3.2 (1996): 369-370.
Chicago
Cimoli, G., Parodi, S., Russo, P."Interferon-gamma enhances TNF sensitivity in A172 human glioblastoma cell line". Oncology Reports 3, no. 2 (1996): 369-370. https://doi.org/10.3892/or.3.2.369