Regulation of expression of the hepatocyte growth factor scatter factor receptor, c-met, by cytokines

  • Authors:
    • S Hiscox
    • W Jiang
  • View Affiliations

  • Published online on: May 1, 1996     https://doi.org/10.3892/or.3.3.553
  • Pages: 553-557
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Abstract

The c-met proto-oncogene product is a 190 kDa heterodimeric receptor tyrosine kinase activated by the binding of its li,gand, hepatocyte growth factor/scatter factor (HGF/SF), a cytokine known to stimulate cell growth, motility and morphogenesis. Altered expression of c-met receptor levels in tumour cells may therefore play an important role in regulating the metastatic progression of cancers. We have determined the effects of a number of cytokines on c-met expression in the colon cancer cell line HT29. We report that c-met message and protein levels are up-regulated by the cytokines IL-5, IL-10, TGF-beta, PDGF and basic FCF while down-regulation occurred after treatment with IFN-gamma. We conclude that up-regulation of the HGF/SF receptor in vivo by the above cytokines may enhance tumour cell sensitivity to HGF/SF and therefore be an important step in the progression of metastatic spread.

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May 1996
Volume 3 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hiscox S and Jiang W: Regulation of expression of the hepatocyte growth factor scatter factor receptor, c-met, by cytokines. Oncol Rep 3: 553-557, 1996.
APA
Hiscox, S., & Jiang, W. (1996). Regulation of expression of the hepatocyte growth factor scatter factor receptor, c-met, by cytokines. Oncology Reports, 3, 553-557. https://doi.org/10.3892/or.3.3.553
MLA
Hiscox, S., Jiang, W."Regulation of expression of the hepatocyte growth factor scatter factor receptor, c-met, by cytokines". Oncology Reports 3.3 (1996): 553-557.
Chicago
Hiscox, S., Jiang, W."Regulation of expression of the hepatocyte growth factor scatter factor receptor, c-met, by cytokines". Oncology Reports 3, no. 3 (1996): 553-557. https://doi.org/10.3892/or.3.3.553