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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 1996 Volume 3 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Could thymostimulin prevent hepatocellular carcinoma occurrence in patients with liver cirrhosis?

  • Authors:
    • G Palmieri
    • E Biondi
    • A Morabito
    • A Rea
    • A Bianco

  • View Affiliations / Copyright

    Affiliations: Affliations not specified
  • Pages: 655-656
    |
    Published online on: July 1, 1996
       https://doi.org/10.3892/or.3.4.655
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Abstract

On the basis of a possible pathogenetic role of immunodepression in the development of hepatocellular carcinoma in patients with chronic hepatitis B/C viral infection and liver cirrhosis, we treated 34 liver cirrhosis patients (M/F 24/10; age: 14 pts less than or equal to 60 years, 20>60; Performance status: 22 0-1, 12 2-3; Childs' grade: 21 A, 13 B; ascites yes/not: 4/30) employing thymostimulin (TST), at the dosage of 50 mg/m(2) i.m. 3 times a week, until death or severe toxicity occurrence. Etiology of cirrhosis was viral in all cases. The patients were followed up every 3 months by means of clinical examination and biochemical analyses; every 6 months by checking viral serum markers, alpha-fetoprotein and by means of ultrasounds. To date, 34 patients have been treated, with a median follow-up of 6 (1-8) years. No occurrence of hepatocellular carcinoma has been observed, with a statistically significant difference between observed and expected HCC (p<0.05). Thymostimulin treatment was well tolerated. Our data seem to suggest that the immunomodulating treatment could significantly reduce the risk of HCC occurrence in patients with liver cirrhosis.

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Copy and paste a formatted citation
Spandidos Publications style
Palmieri G, Biondi E, Morabito A, Rea A and Bianco A: Could thymostimulin prevent hepatocellular carcinoma occurrence in patients with liver cirrhosis?. Oncol Rep 3: 655-656, 1996.
APA
Palmieri, G., Biondi, E., Morabito, A., Rea, A., & Bianco, A. (1996). Could thymostimulin prevent hepatocellular carcinoma occurrence in patients with liver cirrhosis?. Oncology Reports, 3, 655-656. https://doi.org/10.3892/or.3.4.655
MLA
Palmieri, G., Biondi, E., Morabito, A., Rea, A., Bianco, A."Could thymostimulin prevent hepatocellular carcinoma occurrence in patients with liver cirrhosis?". Oncology Reports 3.4 (1996): 655-656.
Chicago
Palmieri, G., Biondi, E., Morabito, A., Rea, A., Bianco, A."Could thymostimulin prevent hepatocellular carcinoma occurrence in patients with liver cirrhosis?". Oncology Reports 3, no. 4 (1996): 655-656. https://doi.org/10.3892/or.3.4.655
Copy and paste a formatted citation
x
Spandidos Publications style
Palmieri G, Biondi E, Morabito A, Rea A and Bianco A: Could thymostimulin prevent hepatocellular carcinoma occurrence in patients with liver cirrhosis?. Oncol Rep 3: 655-656, 1996.
APA
Palmieri, G., Biondi, E., Morabito, A., Rea, A., & Bianco, A. (1996). Could thymostimulin prevent hepatocellular carcinoma occurrence in patients with liver cirrhosis?. Oncology Reports, 3, 655-656. https://doi.org/10.3892/or.3.4.655
MLA
Palmieri, G., Biondi, E., Morabito, A., Rea, A., Bianco, A."Could thymostimulin prevent hepatocellular carcinoma occurrence in patients with liver cirrhosis?". Oncology Reports 3.4 (1996): 655-656.
Chicago
Palmieri, G., Biondi, E., Morabito, A., Rea, A., Bianco, A."Could thymostimulin prevent hepatocellular carcinoma occurrence in patients with liver cirrhosis?". Oncology Reports 3, no. 4 (1996): 655-656. https://doi.org/10.3892/or.3.4.655
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