Influence of verapamil on tumour cell growth in vitro following treatment with antiblastic drugs

  • Authors:
    • E Berti
    • S DAncona
    • E Ragazzi
    • T Berti
  • View Affiliations

  • Published online on: September 1, 1996     https://doi.org/10.3892/or.3.5.895
  • Pages: 895-898
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Abstract

The effect of antiblastic drugs with different mechanisms of action has been investigated in LoVo cells (on the resistant line LoVo R and the parental LoVo S) for 48 h and for further 24 h in drug-free medium (recovery time) in order to evaluate drug action after its removal. Our results show that the drug effect persists in time, particularly in LoVo R cells. The inhibitory effect on cell growth was enhanced when the drugs were associated with verapamil, while no difference was detected with cisplatin and 4-hydroperoxycyclophosphamide, drugs which are not involved in P-glycoprotein-mediated multidrug resistance. These results demonstrate that verapamil is an effective agent in association with those drugs which are actively transported out of the tumour cells, while it is ineffective on drugs which can induce resistance by different mechanisms.

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September 1996
Volume 3 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Berti E, DAncona S, Ragazzi E and Berti T: Influence of verapamil on tumour cell growth in vitro following treatment with antiblastic drugs. Oncol Rep 3: 895-898, 1996
APA
Berti, E., DAncona, S., Ragazzi, E., & Berti, T. (1996). Influence of verapamil on tumour cell growth in vitro following treatment with antiblastic drugs. Oncology Reports, 3, 895-898. https://doi.org/10.3892/or.3.5.895
MLA
Berti, E., DAncona, S., Ragazzi, E., Berti, T."Influence of verapamil on tumour cell growth in vitro following treatment with antiblastic drugs". Oncology Reports 3.5 (1996): 895-898.
Chicago
Berti, E., DAncona, S., Ragazzi, E., Berti, T."Influence of verapamil on tumour cell growth in vitro following treatment with antiblastic drugs". Oncology Reports 3, no. 5 (1996): 895-898. https://doi.org/10.3892/or.3.5.895