Histogenesis of the gastric differentiated adenocarcinoma-expression of oncogene protein products and mucin histochemistry in minute gastric cancer

Wada,R; Abe,H; Matsukuma,S; Kuwabara,N; Suda,K

doi:10.3892/or.3.5.901

September 1996 Volume 3 Issue 5

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September 1996 Volume 3 Issue 5

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Article

Histogenesis of the gastric differentiated adenocarcinoma-expression of oncogene protein products and mucin histochemistry in minute gastric cancer

Authors:
- R Wada
- H Abe
- S Matsukuma
- N Kuwabara
- K Suda
View Affiliations / Copyright

Affiliations: JUNTENDO UNIV,SCH MED,DEPT PATHOL 1,TOKYO 113,JAPAN.
Pages: 901-905
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Published online on: September 1, 1996

https://doi.org/10.3892/or.3.5.901
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Abstract

Examination of the immuno-overexpression for myc, ras, c-erbB-2 and p53 and the mucin histochemistry of the gastric adenocarcinoma cells at the earlier stages were performed using 12 lesions of the well differentiated tubular adenocarcinomas, less than 1 mm in greatest dimension (G-ade-1), from the pyloric gland or the intermediate area of the surgically resected stomach. The G-ade-1 had a high frequency of expression of oncogene myc (58%) and of the cancer suppressor gene p53 (83%), while almost no expression of ras or c-erbB-2 was observed. All lesions of G-ade-1 were positive for acid mucin staining, and 8/12 lesions (67%) also for sulfomucin, in 4/12 lesions (33%) gastric native mucin was observed. The adjacent mucosa to all G-ade-1 lesions in this study showed chronic gastritis with incomplete intestinal metaplasia. These results suggested that the human gastric differentiated adenocarcinoma developed accompanying the abnormal expression of myc and p53 with reference to intestinal metaplasia, and that these carcinoma cells always had acid mucin, often the colonic native mucin as sulfomucin, and also sometimes gastric native mucin in the earlier stages.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Histogenesis of the gastric differentiated adenocarcinoma-expression of oncogene protein products and mucin histochemistry in minute gastric cancer

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Abstract

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