Tamoxifen inhibits phorbol ester-induced reactive nitrogen intermediate production by U937 cells
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- Published online on: September 1, 1996 https://doi.org/10.3892/or.3.5.935
- Pages: 935-937
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Abstract
Phorbol 12-myristate 13-acetate (PMA) enhanced nitrite production by U937 cells. During a 6-day treatment of U937 cells with PMA (200 nM-1000 nM) there was a significant increase (p<0.001) in NO2- secreted into the culture medium. Treatment of the same cells with tamoxifen (10(-10) M -10(-6) M) had no effect on nitrite production. However, tamoxifen was able to significantly (p<0.05) down-regulate PMA-enhanced nitrite production by U937 cells.
