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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 1996 Volume 3 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1996 Volume 3 Issue 5

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Article

nm23 and p53 expression

  • Authors:
    • C Midulla
    • P DeIorio
    • C Valli
    • A Felici
    • D Serpieri
    • L Marzetti
    • I Nofroni
    • A Vecchione

  • View Affiliations / Copyright

    Affiliations: UNIV ROMA LA SAPIENZA,INST OBSTET & GYNECOL 1,I-00161 ROME,ITALY.
  • Pages: 957-961
    |
    Published online on: September 1, 1996
       https://doi.org/10.3892/or.3.5.957
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Abstract

Breast cancer is a common malignancy and the modalities and the aggressiveness of treatment strategies are variable and depend on information regarding the biological characteristics and behavior of an individual tumor. Therefore, to improve overall survival it is important to identify and select lymph node negative patients at high risk who would benefit from adjuvant therapy. Besides prognostic factors such as lymph node status, hormone receptor status and histopathologic parameters, nm23 antimetastatic gene and the p53 protein were studied in 32 breast cancer patients. Positive staining for nm23 was inversely associated with lymph node involvement in 82.4% of the cases. Most of the non-diploid lesions (70.8%) showed a high protein expression. Positive immunostaining for p53 was present in 28.1% of the cases and was strongly correlated with prognostic indicators such as necrosis and histologic grading. Tumor grade, DNA ploidy and lymph node metastasis were not significantly correlated with p53 protein expression. In this study, all the prognostic indicators studied, satisfactorily explain the important characteristics of the biologic behaviour of breast cancer, but the detection of lymph node metastasis is still the most accurate prognostic factor utilized for a predictive role in disease recurrence.

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Copy and paste a formatted citation
Spandidos Publications style
Midulla C, DeIorio P, Valli C, Felici A, Serpieri D, Marzetti L, Nofroni I and Vecchione A: nm23 and p53 expression. Oncol Rep 3: 957-961, 1996.
APA
Midulla, C., DeIorio, P., Valli, C., Felici, A., Serpieri, D., Marzetti, L. ... Vecchione, A. (1996). nm23 and p53 expression. Oncology Reports, 3, 957-961. https://doi.org/10.3892/or.3.5.957
MLA
Midulla, C., DeIorio, P., Valli, C., Felici, A., Serpieri, D., Marzetti, L., Nofroni, I., Vecchione, A."nm23 and p53 expression". Oncology Reports 3.5 (1996): 957-961.
Chicago
Midulla, C., DeIorio, P., Valli, C., Felici, A., Serpieri, D., Marzetti, L., Nofroni, I., Vecchione, A."nm23 and p53 expression". Oncology Reports 3, no. 5 (1996): 957-961. https://doi.org/10.3892/or.3.5.957
Copy and paste a formatted citation
x
Spandidos Publications style
Midulla C, DeIorio P, Valli C, Felici A, Serpieri D, Marzetti L, Nofroni I and Vecchione A: nm23 and p53 expression. Oncol Rep 3: 957-961, 1996.
APA
Midulla, C., DeIorio, P., Valli, C., Felici, A., Serpieri, D., Marzetti, L. ... Vecchione, A. (1996). nm23 and p53 expression. Oncology Reports, 3, 957-961. https://doi.org/10.3892/or.3.5.957
MLA
Midulla, C., DeIorio, P., Valli, C., Felici, A., Serpieri, D., Marzetti, L., Nofroni, I., Vecchione, A."nm23 and p53 expression". Oncology Reports 3.5 (1996): 957-961.
Chicago
Midulla, C., DeIorio, P., Valli, C., Felici, A., Serpieri, D., Marzetti, L., Nofroni, I., Vecchione, A."nm23 and p53 expression". Oncology Reports 3, no. 5 (1996): 957-961. https://doi.org/10.3892/or.3.5.957
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