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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 1996 Volume 3 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1996 Volume 3 Issue 6

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Article

Evidence for common signalling pathways of GnRH receptor and Fas in tumors

  • Authors:
    • T Fuseya
    • A Imai
    • S Horibe
    • A Takagi
    • T Tamaya

  • View Affiliations / Copyright

    Affiliations: GIFU UNIV,SCH MED,DEPT OBSTET & GYNECOL,GIFU 500,JAPAN.
  • Pages: 1111-1113
    |
    Published online on: November 1, 1996
       https://doi.org/10.3892/or.3.6.1111
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Abstract

Fas, a cell surface receptor, mediates cell death by means of apoptosis in a variety of cell types. GnRH receptor-bearing tumors undergo apoptosis with GnRH analogs. To examine whether Fas and GnRH receptor share the same signal transduction pathway, we attempted to detect Fas-linked responses within plasma membrane isolated from GnRH receptor-bearing tumors. Surgically removed gynecological tumors were screened for Fas and GnRH receptor expression prior to analyses. The plasma membranes from these tumors responded to anti-Fas antibody (N-18) exposure with an inhibition in phosphatidylinositol (PtdIns) kinase activity, analogous to response to GnRH analog (buserelin) exposure; the activity was measured as phosphorylation from [gamma-P-32]ATP of exogenous substrate PtdIns by the purified plasma membranes. This inhibition was dependent on the N-18 dose, and a maximal effect occurred at 300 ng/ml with 60% decrease in PtdIns phosphorylation. The maximal inhibitory effects of N-18 and buserelin were not additive on PtdIns kinase inhibition; inhibition by both N-18 and GnRH analog was no greater than with either one alone. These data might suggest that there may be at least some similarity in signal transduction pathway utilized by GnRH analogs and Fas ligands.

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Copy and paste a formatted citation
Spandidos Publications style
Fuseya T, Imai A, Horibe S, Takagi A and Tamaya T: Evidence for common signalling pathways of GnRH receptor and Fas in tumors. Oncol Rep 3: 1111-1113, 1996.
APA
Fuseya, T., Imai, A., Horibe, S., Takagi, A., & Tamaya, T. (1996). Evidence for common signalling pathways of GnRH receptor and Fas in tumors. Oncology Reports, 3, 1111-1113. https://doi.org/10.3892/or.3.6.1111
MLA
Fuseya, T., Imai, A., Horibe, S., Takagi, A., Tamaya, T."Evidence for common signalling pathways of GnRH receptor and Fas in tumors". Oncology Reports 3.6 (1996): 1111-1113.
Chicago
Fuseya, T., Imai, A., Horibe, S., Takagi, A., Tamaya, T."Evidence for common signalling pathways of GnRH receptor and Fas in tumors". Oncology Reports 3, no. 6 (1996): 1111-1113. https://doi.org/10.3892/or.3.6.1111
Copy and paste a formatted citation
x
Spandidos Publications style
Fuseya T, Imai A, Horibe S, Takagi A and Tamaya T: Evidence for common signalling pathways of GnRH receptor and Fas in tumors. Oncol Rep 3: 1111-1113, 1996.
APA
Fuseya, T., Imai, A., Horibe, S., Takagi, A., & Tamaya, T. (1996). Evidence for common signalling pathways of GnRH receptor and Fas in tumors. Oncology Reports, 3, 1111-1113. https://doi.org/10.3892/or.3.6.1111
MLA
Fuseya, T., Imai, A., Horibe, S., Takagi, A., Tamaya, T."Evidence for common signalling pathways of GnRH receptor and Fas in tumors". Oncology Reports 3.6 (1996): 1111-1113.
Chicago
Fuseya, T., Imai, A., Horibe, S., Takagi, A., Tamaya, T."Evidence for common signalling pathways of GnRH receptor and Fas in tumors". Oncology Reports 3, no. 6 (1996): 1111-1113. https://doi.org/10.3892/or.3.6.1111
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