Expression of epidermal growth factor and its receptor in gestational trophoblastic diseases

  • Authors:
    • M John
    • T Rajalekshmy
    • B Nair
    • J Augustine
    • G Schultz
    • K Nair
    • P Balaram
  • View Affiliations

  • Published online on: January 1, 1997     https://doi.org/10.3892/or.4.1.177
  • Pages: 177-182
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Abstract

Gestational trophoblastic diseases (GTD) is an abnormal condition of the placenta, the incidence of which is very high in the State of Kerala, India. Placentae of normal (50) and molar pregnancy (122) including 52 showing persistent disease were used for the study. EGFR and EGF expression was analyzed by immunohistochemistry using monoclonal antibodies. EGF receptors were quantitated using the I-125 EGF-binding assay and that of EGF was quantitated using isotope labelled antibody to EGF. Tumours with histological diagnosis of invasive moles and choriocarcinoma showed very strong binding of both EGF and EGFR. The present observations also suggest the possibility of presence of mutated EGF receptors in persistent trophoblastic disease.

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January 1997
Volume 4 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
John M, Rajalekshmy T, Nair B, Augustine J, Schultz G, Nair K and Balaram P: Expression of epidermal growth factor and its receptor in gestational trophoblastic diseases. Oncol Rep 4: 177-182, 1997.
APA
John, M., Rajalekshmy, T., Nair, B., Augustine, J., Schultz, G., Nair, K., & Balaram, P. (1997). Expression of epidermal growth factor and its receptor in gestational trophoblastic diseases. Oncology Reports, 4, 177-182. https://doi.org/10.3892/or.4.1.177
MLA
John, M., Rajalekshmy, T., Nair, B., Augustine, J., Schultz, G., Nair, K., Balaram, P."Expression of epidermal growth factor and its receptor in gestational trophoblastic diseases". Oncology Reports 4.1 (1997): 177-182.
Chicago
John, M., Rajalekshmy, T., Nair, B., Augustine, J., Schultz, G., Nair, K., Balaram, P."Expression of epidermal growth factor and its receptor in gestational trophoblastic diseases". Oncology Reports 4, no. 1 (1997): 177-182. https://doi.org/10.3892/or.4.1.177