Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk

  • Authors:
    • E Bowman
    • P Shields
    • N Caporaso
    • M Tucker
    • R Hoover
    • B Trump
    • C Harris
  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/or.4.2.269
  • Pages: 269-272
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Abstract

A 193 base pair repeat polymorphism in the human poly(ADP-ribose) polymerase (PADPRP) pseudogene found on chromosome 13 has been associated with lung cancer, endemic Burkitt lymphoma, B-cell lymphoma, breast cancer and colorectal carcinoma. We investigated the frequency of the PADPRP genetic polymorphism in a hospital-based case-control study of lung cancer for 54 cases and 47 controls. There was a statistically significant difference in allelic frequency between Caucasians and African Americans (p<0.001). For African Americans, the odds ratio for lung cancer and the 'B' allele was 2.38 (95% C.I.=0.73, 7.69) and for Caucasians 0.44 (95% C.I.=0.11, 1.77). The results for the African Americans, however, were not in Hardy-Weinberg equilibrium, although the Caucasians were. Thus, this study, albeit small, does not find that the PADPRP pseudogene duplicated region located on chromosome 13 is a risk factor for lung cancer.

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March 1997
Volume 4 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Bowman E, Shields P, Caporaso N, Tucker M, Hoover R, Trump B and Harris C: Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. Oncol Rep 4: 269-272, 1997
APA
Bowman, E., Shields, P., Caporaso, N., Tucker, M., Hoover, R., Trump, B., & Harris, C. (1997). Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. Oncology Reports, 4, 269-272. https://doi.org/10.3892/or.4.2.269
MLA
Bowman, E., Shields, P., Caporaso, N., Tucker, M., Hoover, R., Trump, B., Harris, C."Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk". Oncology Reports 4.2 (1997): 269-272.
Chicago
Bowman, E., Shields, P., Caporaso, N., Tucker, M., Hoover, R., Trump, B., Harris, C."Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk". Oncology Reports 4, no. 2 (1997): 269-272. https://doi.org/10.3892/or.4.2.269