Immunohistochemical detection of nm23-H1/NDP kinase in childhood thyroid carcinoma

  • Authors:
    • Y Shirahige
    • J Irie
    • K Ashizawa
    • N Yokoyama
    • N Ishikawa
    • T Mimura
    • K Ito
    • S Nagataki
  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/or.4.2.285
  • Pages: 285-288
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Abstract

Childhood thyroid cancer is known to be aggressive. High incidence of lymph node and distant metastasis are characteristic features of these cases. In adult, reduced expression of nm23-H1/nucleoside diphosphate (NDP) kinase has been correlated with cancer invasion and metastasis in some tumor types. Therefore, we examined the expression of nm23-H1 gene product in childhood thyroid carcinomas in Japan. 27 primary thyroid carcinomas and 8 metastatic lymph nodes were analyzed by immunohistochemistry using monoclonal antibody H1-229. 21 out of 23 cases (91%) of papillary carcinomas were positively immunostained, whereas none of the 4 follicular carcinomas showed any immunoreactivity. No correlation was found between the nm23-H1/NDP kinase antigen expression and nodal involvement or distant metastasis in primary tumors. However, only 50% (4 out of 8) of metastatic lymph nodes from papillary carcinoma were positively stained, demonstrating a significant decrease comparing to those of primary sites. These data indicate that the expression of nm23-H1/NDP kinase cannot predict tumor metastatic potential in childhood thyroid cancer.

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March 1997
Volume 4 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Shirahige Y, Irie J, Ashizawa K, Yokoyama N, Ishikawa N, Mimura T, Ito K and Nagataki S: Immunohistochemical detection of nm23-H1/NDP kinase in childhood thyroid carcinoma. Oncol Rep 4: 285-288, 1997
APA
Shirahige, Y., Irie, J., Ashizawa, K., Yokoyama, N., Ishikawa, N., Mimura, T. ... Nagataki, S. (1997). Immunohistochemical detection of nm23-H1/NDP kinase in childhood thyroid carcinoma. Oncology Reports, 4, 285-288. https://doi.org/10.3892/or.4.2.285
MLA
Shirahige, Y., Irie, J., Ashizawa, K., Yokoyama, N., Ishikawa, N., Mimura, T., Ito, K., Nagataki, S."Immunohistochemical detection of nm23-H1/NDP kinase in childhood thyroid carcinoma". Oncology Reports 4.2 (1997): 285-288.
Chicago
Shirahige, Y., Irie, J., Ashizawa, K., Yokoyama, N., Ishikawa, N., Mimura, T., Ito, K., Nagataki, S."Immunohistochemical detection of nm23-H1/NDP kinase in childhood thyroid carcinoma". Oncology Reports 4, no. 2 (1997): 285-288. https://doi.org/10.3892/or.4.2.285