Effects of gelonin immunoconjugate of monoclonal antibody MSN-1 to endometrial adenocarcinoma on antigen-producing tumor cells in vitro

  • Authors:
    • Y Kaneta
    • K Tsukazaki
    • K Kubushiro
    • R Aoki
    • M Sakayori
    • M Ueda
    • S Nozawa
  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/or.4.2.331
  • Pages: 331-336
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Missile therapy, which destroys cancer cells specifically, has been considered to be an effective modality for treatment of carcinoma. We have developed a monoclonal antibody MSN-1 (immunoglobulin class: IgM), of which the immunogen is the endometrial adenocarcinoma cell line SNG-II, which strongly reacts with endometrial adenocarcinomas. We describe an immunoconjugate consisting of the MSN-1 and a plant hemitoxin named gelonin which has revealed to assume selective cytotoxicity against the SNG-II in a colony formation assay in vitro. The results of our study suggest that the 'inhibitory concentration' or IC50, of the MSN-1-gelonin immunoconjugate against the SNG-II was 188 fold that of gelonin alone. These results indicated that the MSN-1-gelonin immunoconjugate exhibited highly selective cytotoxicity to endometrial adenocarcinoma, which expressed an epitope against the MSN-1, and it is suggested that the MSN-1-gelonin immunoconjugate has possibility of clinical application to treatment of endometrial adenocarcinomas.

Related Articles

Journal Cover

March 1997
Volume 4 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kaneta Y, Tsukazaki K, Kubushiro K, Aoki R, Sakayori M, Ueda M and Nozawa S: Effects of gelonin immunoconjugate of monoclonal antibody MSN-1 to endometrial adenocarcinoma on antigen-producing tumor cells in vitro. Oncol Rep 4: 331-336, 1997
APA
Kaneta, Y., Tsukazaki, K., Kubushiro, K., Aoki, R., Sakayori, M., Ueda, M., & Nozawa, S. (1997). Effects of gelonin immunoconjugate of monoclonal antibody MSN-1 to endometrial adenocarcinoma on antigen-producing tumor cells in vitro. Oncology Reports, 4, 331-336. https://doi.org/10.3892/or.4.2.331
MLA
Kaneta, Y., Tsukazaki, K., Kubushiro, K., Aoki, R., Sakayori, M., Ueda, M., Nozawa, S."Effects of gelonin immunoconjugate of monoclonal antibody MSN-1 to endometrial adenocarcinoma on antigen-producing tumor cells in vitro". Oncology Reports 4.2 (1997): 331-336.
Chicago
Kaneta, Y., Tsukazaki, K., Kubushiro, K., Aoki, R., Sakayori, M., Ueda, M., Nozawa, S."Effects of gelonin immunoconjugate of monoclonal antibody MSN-1 to endometrial adenocarcinoma on antigen-producing tumor cells in vitro". Oncology Reports 4, no. 2 (1997): 331-336. https://doi.org/10.3892/or.4.2.331