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Vascular endothelial growth factor expression correlates with hematogenous metastasis and prognosis in colorectal carcinoma

  • Authors:
    • S Kang
    • K Maeda
    • Y Chung
    • N Onoda
    • Y Ogawa
    • S Takatsuka
    • M Ogawa
    • T Sawada
    • B Nakata
    • Y Nishiguchi
    • T Ikehara
    • M Okuno
    • M Sowa

  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/or.4.2.381
  • Pages: 381-384
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Abstract

We investigated the expression of vascular endothelial growth factor (VEGF) in 175 colorectal carcinomas by immunohistochemistry. VEGF expression was correlated with advanced TNM stage (III, IV), advanced T stage (T3, T4), vessel involvement, lymph node metastasis, and liver metastasis. With regard to the prognosis, both overall and relapse-free survival was significantly poorer, and furthermore, the hematogenous recurrences were significantly more commonly found in the patients with VEGF-positive tumors. VEGF expresion in colorectal carcinomas may have a substantial value in predicting those patients at high risk for hematogenous recurrence after surgery.

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Journal Cover

March 1997
Volume 4 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Kang S, Maeda K, Chung Y, Onoda N, Ogawa Y, Takatsuka S, Ogawa M, Sawada T, Nakata B, Nishiguchi Y, Nishiguchi Y, et al: Vascular endothelial growth factor expression correlates with hematogenous metastasis and prognosis in colorectal carcinoma. Oncol Rep 4: 381-384, 1997
APA
Kang, S., Maeda, K., Chung, Y., Onoda, N., Ogawa, Y., Takatsuka, S. ... Sowa, M. (1997). Vascular endothelial growth factor expression correlates with hematogenous metastasis and prognosis in colorectal carcinoma. Oncology Reports, 4, 381-384. https://doi.org/10.3892/or.4.2.381
MLA
Kang, S., Maeda, K., Chung, Y., Onoda, N., Ogawa, Y., Takatsuka, S., Ogawa, M., Sawada, T., Nakata, B., Nishiguchi, Y., Ikehara, T., Okuno, M., Sowa, M."Vascular endothelial growth factor expression correlates with hematogenous metastasis and prognosis in colorectal carcinoma". Oncology Reports 4.2 (1997): 381-384.
Chicago
Kang, S., Maeda, K., Chung, Y., Onoda, N., Ogawa, Y., Takatsuka, S., Ogawa, M., Sawada, T., Nakata, B., Nishiguchi, Y., Ikehara, T., Okuno, M., Sowa, M."Vascular endothelial growth factor expression correlates with hematogenous metastasis and prognosis in colorectal carcinoma". Oncology Reports 4, no. 2 (1997): 381-384. https://doi.org/10.3892/or.4.2.381