Persistent alpha 1 integrin subunit expression in human neuroblastoma cell lines which overexpress N-myc and downregulate other integrin subunits

  • Authors:
    • R Judware
    • L Culp
  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/or.4.2.433
  • Pages: 433-437
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Abstract

Neuroblastoma is characterized by amplification and overexpression of N-myc. N-myc down-regulates expression of the beta 1 integrin extracellular matrix receptor, however, some beta 1 was found on the surface of N-myc overexpressing neuroblastoma cell lines. It was determined that the alpha 1 subunit is expressed in the cells, associates with beta 1 and is present on the cell surface. Interestingly, the level of alpha 1 was reduced marginally when compared to beta 1. Finally, overexpression of N-myc alters cell morphology on extracellular matrix proteins with persistence of alpha 1 beta 1-dependent responses. Our work supports the conclusion that altered integrin expression may be an important factor in human neuroblastoma.

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March 1997
Volume 4 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Judware R and Judware R: Persistent alpha 1 integrin subunit expression in human neuroblastoma cell lines which overexpress N-myc and downregulate other integrin subunits. Oncol Rep 4: 433-437, 1997
APA
Judware, R., & Judware, R. (1997). Persistent alpha 1 integrin subunit expression in human neuroblastoma cell lines which overexpress N-myc and downregulate other integrin subunits. Oncology Reports, 4, 433-437. https://doi.org/10.3892/or.4.2.433
MLA
Judware, R., Culp, L."Persistent alpha 1 integrin subunit expression in human neuroblastoma cell lines which overexpress N-myc and downregulate other integrin subunits". Oncology Reports 4.2 (1997): 433-437.
Chicago
Judware, R., Culp, L."Persistent alpha 1 integrin subunit expression in human neuroblastoma cell lines which overexpress N-myc and downregulate other integrin subunits". Oncology Reports 4, no. 2 (1997): 433-437. https://doi.org/10.3892/or.4.2.433