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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 1997 Volume 4 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1997 Volume 4 Issue 2

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Article

DNA ploidy in hepatic cirrhosis, dysplasia and carcinoma

  • Authors:
    • S Eissa
    • M Wahed
    • A Ismail
    • K Amer
    • A Khalifa
    • A ElNaggar

  • View Affiliations / Copyright

    Affiliations: UNIV TEXAS,MD ANDERSON CANC CTR,DEPT PATHOL,HOUSTON,TX 77030. AIN SHAMS UNIV,FAC MED,DEPT BIOCHEM,ONCOL DIAGNOST UNIT,CAIRO,EGYPT. AIN SHAMS UNIV,FAC MED,DEPT SURG,CAIRO,EGYPT. MENOUFIA FAC MED,DEPT PATHOL,MENOUFIA,EGYPT.
  • Pages: 443-445
    |
    Published online on: March 1, 1997
       https://doi.org/10.3892/or.4.2.443
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Abstract

Hepatocellular carcinoma (HCC) is the most common and aggressive form of primary liver tumors. The evolution and the putative association of this neoplasm with hepatic cirrhosis and liver cell dysplasia remain uncertain. We analyzed the DNA ploidy by flow cytometry in a cohort of 130 liver specimens representing liver cirrhosis, hepatic cell dysplasia and hepatocellular carcinoma to determine the incidence and potential biological relevance of this feature. Our results show that four (8.0%) of the 50 cirrhotic lesions, four (26.7%) of 15 dysplastic, and 51 (78.5%) of the 65 HCC manifested DNA aneuploidy. Moreover, DNA aneuploidy was manifested in 60% of histologically negative hepatic resection margins of HCC. Our results indicate that: i) the presence of DNA aneuploidy in some cirrhotic livers and liver cell dysplasias support the potential evolution of HCC from a subset of these lesions that harbor such clonal alterations, ii) DNA aneuploidy in histologically negative resection margins of HCC in some cases support the concept of field cancerization in these tumors and iii) the predominance of DNA aneuploidy and high proliferative index (PI) in liver cell carcinomas underscore their aggressive biological behavior.

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Copy and paste a formatted citation
Spandidos Publications style
Eissa S, Wahed M, Ismail A, Amer K, Khalifa A and ElNaggar A: DNA ploidy in hepatic cirrhosis, dysplasia and carcinoma. Oncol Rep 4: 443-445, 1997.
APA
Eissa, S., Wahed, M., Ismail, A., Amer, K., Khalifa, A., & ElNaggar, A. (1997). DNA ploidy in hepatic cirrhosis, dysplasia and carcinoma. Oncology Reports, 4, 443-445. https://doi.org/10.3892/or.4.2.443
MLA
Eissa, S., Wahed, M., Ismail, A., Amer, K., Khalifa, A., ElNaggar, A."DNA ploidy in hepatic cirrhosis, dysplasia and carcinoma". Oncology Reports 4.2 (1997): 443-445.
Chicago
Eissa, S., Wahed, M., Ismail, A., Amer, K., Khalifa, A., ElNaggar, A."DNA ploidy in hepatic cirrhosis, dysplasia and carcinoma". Oncology Reports 4, no. 2 (1997): 443-445. https://doi.org/10.3892/or.4.2.443
Copy and paste a formatted citation
x
Spandidos Publications style
Eissa S, Wahed M, Ismail A, Amer K, Khalifa A and ElNaggar A: DNA ploidy in hepatic cirrhosis, dysplasia and carcinoma. Oncol Rep 4: 443-445, 1997.
APA
Eissa, S., Wahed, M., Ismail, A., Amer, K., Khalifa, A., & ElNaggar, A. (1997). DNA ploidy in hepatic cirrhosis, dysplasia and carcinoma. Oncology Reports, 4, 443-445. https://doi.org/10.3892/or.4.2.443
MLA
Eissa, S., Wahed, M., Ismail, A., Amer, K., Khalifa, A., ElNaggar, A."DNA ploidy in hepatic cirrhosis, dysplasia and carcinoma". Oncology Reports 4.2 (1997): 443-445.
Chicago
Eissa, S., Wahed, M., Ismail, A., Amer, K., Khalifa, A., ElNaggar, A."DNA ploidy in hepatic cirrhosis, dysplasia and carcinoma". Oncology Reports 4, no. 2 (1997): 443-445. https://doi.org/10.3892/or.4.2.443
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