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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 1997 Volume 4 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1997 Volume 4 Issue 3

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Article

Growth-suppressive activities of serine protease inhibitors, FOY-305, ONO-3403 and FO-349 toward human carcinoma cells

  • Authors:
    • M Ohkoshi
    • T Denda
    • T Hiwasa

  • View Affiliations / Copyright

    Affiliations: CHIBA CANC CTR HOSP,DIV CLIN LAB,CHIBA 260,JAPAN. CHIBA CANC CTR RES INST,DIV BIOCHEM,CHUO KU,CHIBA 260,JAPAN.
  • Pages: 521-523
    |
    Published online on: May 1, 1997
       https://doi.org/10.3892/or.4.3.521
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Abstract

FOY-305 is a synthetic serine protease inhibitor and ONO-3403 and FO-349 are its derivatives. The effects of these compounds on the proliferation of several human carcinoma cell lines were investigated in vitro by MTT colorimetric assay. ONO-3403 showed the most potent growth-inhibitory activity among these protease inhibitors. The half maximum inhibition concentrations of ONO-3403 toward BxPC-3 pancreatic carcinoma, T24 bladder carcinoma and A431 epidermoid carcinoma cells were 20-30 mu g/ml whereas those toward pancreatic carcinomas, PANC-1 and Mia PaCa-2, were 60-80 mu g/ml. Since FOY-305 has been shown to be effective in chemotherapy for human oral cancer, ONO-3403 is expected to be a more effective anticancer drug.

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Copy and paste a formatted citation
Spandidos Publications style
Ohkoshi M, Denda T and Hiwasa T: Growth-suppressive activities of serine protease inhibitors, FOY-305, ONO-3403 and FO-349 toward human carcinoma cells. Oncol Rep 4: 521-523, 1997.
APA
Ohkoshi, M., Denda, T., & Hiwasa, T. (1997). Growth-suppressive activities of serine protease inhibitors, FOY-305, ONO-3403 and FO-349 toward human carcinoma cells. Oncology Reports, 4, 521-523. https://doi.org/10.3892/or.4.3.521
MLA
Ohkoshi, M., Denda, T., Hiwasa, T."Growth-suppressive activities of serine protease inhibitors, FOY-305, ONO-3403 and FO-349 toward human carcinoma cells". Oncology Reports 4.3 (1997): 521-523.
Chicago
Ohkoshi, M., Denda, T., Hiwasa, T."Growth-suppressive activities of serine protease inhibitors, FOY-305, ONO-3403 and FO-349 toward human carcinoma cells". Oncology Reports 4, no. 3 (1997): 521-523. https://doi.org/10.3892/or.4.3.521
Copy and paste a formatted citation
x
Spandidos Publications style
Ohkoshi M, Denda T and Hiwasa T: Growth-suppressive activities of serine protease inhibitors, FOY-305, ONO-3403 and FO-349 toward human carcinoma cells. Oncol Rep 4: 521-523, 1997.
APA
Ohkoshi, M., Denda, T., & Hiwasa, T. (1997). Growth-suppressive activities of serine protease inhibitors, FOY-305, ONO-3403 and FO-349 toward human carcinoma cells. Oncology Reports, 4, 521-523. https://doi.org/10.3892/or.4.3.521
MLA
Ohkoshi, M., Denda, T., Hiwasa, T."Growth-suppressive activities of serine protease inhibitors, FOY-305, ONO-3403 and FO-349 toward human carcinoma cells". Oncology Reports 4.3 (1997): 521-523.
Chicago
Ohkoshi, M., Denda, T., Hiwasa, T."Growth-suppressive activities of serine protease inhibitors, FOY-305, ONO-3403 and FO-349 toward human carcinoma cells". Oncology Reports 4, no. 3 (1997): 521-523. https://doi.org/10.3892/or.4.3.521
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