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Treatment of human cancers by NO-releasing reagents related to Mn-SOD

  • Authors:
    • H Takeshita
    • K Isobe
    • S Akiyama
    • K Ito
    • Y Kasai
    • I Nakashima
    • H Takagi

  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/or.4.3.603
  • Pages: 603-606
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Abstract

Nitric oxide (NO) plays various roles in organisms, including its anti-tumor effect. But it was not well known how NO actually influences human cancer cells and destroys them. We investigated the relation between NO and SODs using S-nitroso-N-acetyl penicillamine (SNAP), an NO releasing reagent. In several cancer cells treated with SNAP, the expression of manganese-superoxide dismutase (Mn-SOD) mRNA and the enzymatic activity of Mn-SOD were both enhanced. These results suggest that some human cancers which are resistant to NO may enhance the expression of Mn-SOD in order to protect themselves against NO radicals. Such mechanism is also expected to offer a clue to the practical use of NO donors as an anti-cancer drug.

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Journal Cover

May 1997
Volume 4 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Takeshita H, Isobe K, Akiyama S, Ito K, Kasai Y, Nakashima I and Takagi H: Treatment of human cancers by NO-releasing reagents related to Mn-SOD. Oncol Rep 4: 603-606, 1997
APA
Takeshita, H., Isobe, K., Akiyama, S., Ito, K., Kasai, Y., Nakashima, I., & Takagi, H. (1997). Treatment of human cancers by NO-releasing reagents related to Mn-SOD. Oncology Reports, 4, 603-606. https://doi.org/10.3892/or.4.3.603
MLA
Takeshita, H., Isobe, K., Akiyama, S., Ito, K., Kasai, Y., Nakashima, I., Takagi, H."Treatment of human cancers by NO-releasing reagents related to Mn-SOD". Oncology Reports 4.3 (1997): 603-606.
Chicago
Takeshita, H., Isobe, K., Akiyama, S., Ito, K., Kasai, Y., Nakashima, I., Takagi, H."Treatment of human cancers by NO-releasing reagents related to Mn-SOD". Oncology Reports 4, no. 3 (1997): 603-606. https://doi.org/10.3892/or.4.3.603