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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
May 1997 Volume 4 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 1997 Volume 4 Issue 3

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Article

Decreased expression of MLH1, MSH2, PMS1 and PMS2 in pigmented lesions indicates accumulation of failed DNA repair along with malignant transformation and tumour progression

  • Authors:
    • M Korabiowska
    • H Dengler
    • S Kellner
    • J Stachura
    • A Schauer

  • View Affiliations / Copyright

    Affiliations: UNIV GOTTINGEN,DEPT MED INFORMAT,D-37075 GOTTINGEN,GERMANY. JAGIELLONIAN UNIV,DEPT PATHOL,PL-31531 KRAKOW,POLAND.
  • Pages: 653-655
    |
    Published online on: May 1, 1997
       https://doi.org/10.3892/or.4.3.653
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Abstract

The tumorigenesis of human nonpolyposis colorectal cancer was reported to be connected with the mutations in DNA mismatch repair genes. The main aim of this study was to check the epression of 4 proteins MLH1, MSH2, PMS1 and PMS2 responsible for mismatch DNA repair in naevi and melanomas. Fifty-one naevi, 78 primary melanomas, 30 lymphatic and 7 organ melanoma metastases were stained for the presence of MLH1, MSH2, PMS1 and PMS2. All proteins were preserved in 88% of naevi and only in 37% of primary melanomas, 17% of lymphatic metastases and in none of the distant metastases. The difference of expression of all 4 proteins between naevi and melanomas was highly significant (p<0.01). MLH1 and MSH2 correlated significantly with each other as well with the follow-up of patients. On the basis of our results one can conclude that the defect of mismatch DNA repair plays an important role in both tumorigenesis of melanoma and metastatic spread of tumour.

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Copy and paste a formatted citation
Spandidos Publications style
Korabiowska M, Dengler H, Kellner S, Stachura J and Schauer A: Decreased expression of MLH1, MSH2, PMS1 and PMS2 in pigmented lesions indicates accumulation of failed DNA repair along with malignant transformation and tumour progression. Oncol Rep 4: 653-655, 1997.
APA
Korabiowska, M., Dengler, H., Kellner, S., Stachura, J., & Schauer, A. (1997). Decreased expression of MLH1, MSH2, PMS1 and PMS2 in pigmented lesions indicates accumulation of failed DNA repair along with malignant transformation and tumour progression. Oncology Reports, 4, 653-655. https://doi.org/10.3892/or.4.3.653
MLA
Korabiowska, M., Dengler, H., Kellner, S., Stachura, J., Schauer, A."Decreased expression of MLH1, MSH2, PMS1 and PMS2 in pigmented lesions indicates accumulation of failed DNA repair along with malignant transformation and tumour progression". Oncology Reports 4.3 (1997): 653-655.
Chicago
Korabiowska, M., Dengler, H., Kellner, S., Stachura, J., Schauer, A."Decreased expression of MLH1, MSH2, PMS1 and PMS2 in pigmented lesions indicates accumulation of failed DNA repair along with malignant transformation and tumour progression". Oncology Reports 4, no. 3 (1997): 653-655. https://doi.org/10.3892/or.4.3.653
Copy and paste a formatted citation
x
Spandidos Publications style
Korabiowska M, Dengler H, Kellner S, Stachura J and Schauer A: Decreased expression of MLH1, MSH2, PMS1 and PMS2 in pigmented lesions indicates accumulation of failed DNA repair along with malignant transformation and tumour progression. Oncol Rep 4: 653-655, 1997.
APA
Korabiowska, M., Dengler, H., Kellner, S., Stachura, J., & Schauer, A. (1997). Decreased expression of MLH1, MSH2, PMS1 and PMS2 in pigmented lesions indicates accumulation of failed DNA repair along with malignant transformation and tumour progression. Oncology Reports, 4, 653-655. https://doi.org/10.3892/or.4.3.653
MLA
Korabiowska, M., Dengler, H., Kellner, S., Stachura, J., Schauer, A."Decreased expression of MLH1, MSH2, PMS1 and PMS2 in pigmented lesions indicates accumulation of failed DNA repair along with malignant transformation and tumour progression". Oncology Reports 4.3 (1997): 653-655.
Chicago
Korabiowska, M., Dengler, H., Kellner, S., Stachura, J., Schauer, A."Decreased expression of MLH1, MSH2, PMS1 and PMS2 in pigmented lesions indicates accumulation of failed DNA repair along with malignant transformation and tumour progression". Oncology Reports 4, no. 3 (1997): 653-655. https://doi.org/10.3892/or.4.3.653
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