Epidermal growth factor and its receptor in cervical cancer

  • Authors:
    • S Lakshmi
    • M Nair
    • P Jayaprakash
    • M Pillai
  • View Affiliations

  • Published online on: September 1, 1997     https://doi.org/10.3892/or.4.5.1103
  • Pages: 1103-1106
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Abstract

Epidermal growth factor (EGF) is an important growth factor regulating both normal and malignant cells. The present study analyzes the expression pattern of EGF and its receptor (EGF-R) in 424 cases of various stages of tumor progression in the uterine cervix. In all the samples studied, EGF and EGF-R expression was predominant in the basal or basaloid cells. Increased expression of the two proteins correlated with increasing histological abnormality (dysplasia). In invasive cancer, alteration of EGF expression was more evident than EGF-R. The expression pattern showed significant correlation in the basal and spinal cell layers. This increased expression of EGF observed in dysplastic and malignant cells may be due to overexpression of EGF-R and suggests its role in cellular proliferation.

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September 1997
Volume 4 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Lakshmi S, Nair M, Jayaprakash P and Pillai M: Epidermal growth factor and its receptor in cervical cancer. Oncol Rep 4: 1103-1106, 1997
APA
Lakshmi, S., Nair, M., Jayaprakash, P., & Pillai, M. (1997). Epidermal growth factor and its receptor in cervical cancer. Oncology Reports, 4, 1103-1106. https://doi.org/10.3892/or.4.5.1103
MLA
Lakshmi, S., Nair, M., Jayaprakash, P., Pillai, M."Epidermal growth factor and its receptor in cervical cancer". Oncology Reports 4.5 (1997): 1103-1106.
Chicago
Lakshmi, S., Nair, M., Jayaprakash, P., Pillai, M."Epidermal growth factor and its receptor in cervical cancer". Oncology Reports 4, no. 5 (1997): 1103-1106. https://doi.org/10.3892/or.4.5.1103