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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 1997 Volume 4 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1997 Volume 4 Issue 6

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Article

Comparative inhibition of prostate cell invasion by conformationally flexible and constrained bis(2,6-dioxopiperazine)s

  • Authors:
    • M Wientjes
    • R Stephens
    • A KoolemansBeynen
    • S Eturi
    • D Witiak

  • View Affiliations / Copyright

    Affiliations: OHIO STATE UNIV,COLL PHARM,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL MED,DEPT PATHOL,COLUMBUS,OH 43210.
  • Pages: 1135-1139
    |
    Published online on: November 1, 1997
       https://doi.org/10.3892/or.4.6.1135
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Abstract

Inhibition of the migration of human prostate cancer PC-3 cells by a series of 18 conformationally flexible and constrained bis(2,6-dioxopiperazine)s including selected bis(morpholinomethyl) derivatives was investigated in vitro using the Matrigel invasion assay. The anti-invasion effects were compared to the cytotoxic effects of these experimental drugs. The parent conformationally mobile ICRF-159 (razoxane) and its dextrorotatory isomer ICRF-187 (dexrazoxane) inhibited invasion at concentrations that were at least 19-fold lower than their cytotoxic concentrations. This indicates that the anti-invasion effect was achieved independent of cytotoxicity. Seven conformationally constrained compounds were found to have no appreciable anti-invasive activity. Generally, the morpholinomethyl pro-drug derivatives of seven of the dioxopiperazines, exhibited either anti-invasive or cytotoxic activities that were reduced or unchanged relative to the parent molecules. In summary, certain bis(2,6-dioxopiperazine)s exhibit a promising and selective anti-invasion effect in human prostate cells. This activity seems to require a flexible linker allowing for multiple conformational possibilities of the dioxopiperazine rings.

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Copy and paste a formatted citation
Spandidos Publications style
Wientjes M, Stephens R, KoolemansBeynen A, Eturi S and Witiak D: Comparative inhibition of prostate cell invasion by conformationally flexible and constrained bis(2,6-dioxopiperazine)s. Oncol Rep 4: 1135-1139, 1997.
APA
Wientjes, M., Stephens, R., KoolemansBeynen, A., Eturi, S., & Witiak, D. (1997). Comparative inhibition of prostate cell invasion by conformationally flexible and constrained bis(2,6-dioxopiperazine)s. Oncology Reports, 4, 1135-1139. https://doi.org/10.3892/or.4.6.1135
MLA
Wientjes, M., Stephens, R., KoolemansBeynen, A., Eturi, S., Witiak, D."Comparative inhibition of prostate cell invasion by conformationally flexible and constrained bis(2,6-dioxopiperazine)s". Oncology Reports 4.6 (1997): 1135-1139.
Chicago
Wientjes, M., Stephens, R., KoolemansBeynen, A., Eturi, S., Witiak, D."Comparative inhibition of prostate cell invasion by conformationally flexible and constrained bis(2,6-dioxopiperazine)s". Oncology Reports 4, no. 6 (1997): 1135-1139. https://doi.org/10.3892/or.4.6.1135
Copy and paste a formatted citation
x
Spandidos Publications style
Wientjes M, Stephens R, KoolemansBeynen A, Eturi S and Witiak D: Comparative inhibition of prostate cell invasion by conformationally flexible and constrained bis(2,6-dioxopiperazine)s. Oncol Rep 4: 1135-1139, 1997.
APA
Wientjes, M., Stephens, R., KoolemansBeynen, A., Eturi, S., & Witiak, D. (1997). Comparative inhibition of prostate cell invasion by conformationally flexible and constrained bis(2,6-dioxopiperazine)s. Oncology Reports, 4, 1135-1139. https://doi.org/10.3892/or.4.6.1135
MLA
Wientjes, M., Stephens, R., KoolemansBeynen, A., Eturi, S., Witiak, D."Comparative inhibition of prostate cell invasion by conformationally flexible and constrained bis(2,6-dioxopiperazine)s". Oncology Reports 4.6 (1997): 1135-1139.
Chicago
Wientjes, M., Stephens, R., KoolemansBeynen, A., Eturi, S., Witiak, D."Comparative inhibition of prostate cell invasion by conformationally flexible and constrained bis(2,6-dioxopiperazine)s". Oncology Reports 4, no. 6 (1997): 1135-1139. https://doi.org/10.3892/or.4.6.1135
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