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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 1997 Volume 4 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1997 Volume 4 Issue 6

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Article

Reactivity of 87 monoclonal antibodies against tissues in vivo and resting and irradiated endothelial cells in vitro

  • Authors:
    • M Carette
    • J Ponting
    • C Li
    • J Wang
    • R Hunter
    • S Kumar

  • View Affiliations / Copyright

    Affiliations: UNIV MANCHESTER,DEPT PATHOL & RHEUMATOL,MANCHESTER M13 9PT,LANCS,ENGLAND. CHRISTIE HOSP,MANCHESTER,LANCS,ENGLAND. PHARMINGEN,SAN DIEGO,CA.
  • Pages: 1285-1288
    |
    Published online on: November 1, 1997
       https://doi.org/10.3892/or.4.6.1285
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Abstract

Altered expression of vascular endothelial cell (EC) surface antigens in response to irradiation is one of the early events of radiation-induced damage. Using flow cytometry, we investigated the immunocytochemical reactivity of a blind panel comprising 87 mAbs submitted to the endothelial section of the 6th International Workshop on Human Leukocyte Differentiation Antigens with irradiated and resting human dermal microvascular endothelial (HDME) and EA cell lines. Monolayers of irradiated cells received a single 5 Gy dose of 72 h prior to staining but were otherwise treated the same as resting cells. For comparative purposes we have also examined the immunohistochemical reactivity of the mAb panel with EC in ovarian tumour, Wilms' tumour and human placenta. In the flow cytometry experiments 42 and 44 mAbs stained HDME and EA cells respectively and while no antibody stained irradiated but not unirradiated cells, upregulation was seen for CD31, CD34, CD141 and CD146 in irradiated cells. The upregulation of thrombomodulin (CD141) is noteworthy since it is a marker of EC damage and thus may be a useful reagent in investigations of vascular injury. Comparison with tissue staining showed that 21 mAbs were reactive with at least one tissue but not with either EA or HDME cells. Nine mAbs showed no cross reactivity with tissue and of these one reacted with EA cells only.

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Copy and paste a formatted citation
Spandidos Publications style
Carette M, Ponting J, Li C, Wang J, Hunter R and Kumar S: Reactivity of 87 monoclonal antibodies against tissues in vivo and resting and irradiated endothelial cells in vitro. Oncol Rep 4: 1285-1288, 1997.
APA
Carette, M., Ponting, J., Li, C., Wang, J., Hunter, R., & Kumar, S. (1997). Reactivity of 87 monoclonal antibodies against tissues in vivo and resting and irradiated endothelial cells in vitro. Oncology Reports, 4, 1285-1288. https://doi.org/10.3892/or.4.6.1285
MLA
Carette, M., Ponting, J., Li, C., Wang, J., Hunter, R., Kumar, S."Reactivity of 87 monoclonal antibodies against tissues in vivo and resting and irradiated endothelial cells in vitro". Oncology Reports 4.6 (1997): 1285-1288.
Chicago
Carette, M., Ponting, J., Li, C., Wang, J., Hunter, R., Kumar, S."Reactivity of 87 monoclonal antibodies against tissues in vivo and resting and irradiated endothelial cells in vitro". Oncology Reports 4, no. 6 (1997): 1285-1288. https://doi.org/10.3892/or.4.6.1285
Copy and paste a formatted citation
x
Spandidos Publications style
Carette M, Ponting J, Li C, Wang J, Hunter R and Kumar S: Reactivity of 87 monoclonal antibodies against tissues in vivo and resting and irradiated endothelial cells in vitro. Oncol Rep 4: 1285-1288, 1997.
APA
Carette, M., Ponting, J., Li, C., Wang, J., Hunter, R., & Kumar, S. (1997). Reactivity of 87 monoclonal antibodies against tissues in vivo and resting and irradiated endothelial cells in vitro. Oncology Reports, 4, 1285-1288. https://doi.org/10.3892/or.4.6.1285
MLA
Carette, M., Ponting, J., Li, C., Wang, J., Hunter, R., Kumar, S."Reactivity of 87 monoclonal antibodies against tissues in vivo and resting and irradiated endothelial cells in vitro". Oncology Reports 4.6 (1997): 1285-1288.
Chicago
Carette, M., Ponting, J., Li, C., Wang, J., Hunter, R., Kumar, S."Reactivity of 87 monoclonal antibodies against tissues in vivo and resting and irradiated endothelial cells in vitro". Oncology Reports 4, no. 6 (1997): 1285-1288. https://doi.org/10.3892/or.4.6.1285
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