Cytotoxicity of 2-deoxy-D-glucose and its tetra-acetate ester in tumoral cell lines

  • Authors:
    • A Delvaux
    • M Kadiata
    • W Malaisse
  • View Affiliations

  • Published online on: November 1, 1997     https://doi.org/10.3892/or.4.6.1295
  • Pages: 1295-1299
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Abstract

Mouse Lewis lung carcinoma cells (3LL-HH), mouse leukemic cells (L1210), mouse melanoma cells (B16F1), rat gliosarcoma cells (9L), rat hybrid insulin-producing cells (BRIN-BD11) and human hepatocellular carcinoma cells (HepG2) were cultured for 8 to 96 h in the absence or presence of 2-deoxy-D-glucose or its tetra-acetate ester (45 mu M to 0.8 mM). The ester was more efficient than the unesterified glucose analog in decreasing the growth of the tumoral cells, as assessed by either the generation of formazan from 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide or direct cell counting. At high concentration (0.8 mM), the ester even decreased the cell number below its initial value. Even under these conditions, a partial restoration ol-cell growth was observed, however, when the cells were cultured in a control medium after having been exposed for 8 h to 2-deoxy-D-glucose tetraacetate. These findings indicate that such an ester acts as a powerful cytostatic and cytotoxic agent in several tumoral cell lines.

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November 1997
Volume 4 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Delvaux A, Kadiata M and Malaisse W: Cytotoxicity of 2-deoxy-D-glucose and its tetra-acetate ester in tumoral cell lines. Oncol Rep 4: 1295-1299, 1997
APA
Delvaux, A., Kadiata, M., & Malaisse, W. (1997). Cytotoxicity of 2-deoxy-D-glucose and its tetra-acetate ester in tumoral cell lines. Oncology Reports, 4, 1295-1299. https://doi.org/10.3892/or.4.6.1295
MLA
Delvaux, A., Kadiata, M., Malaisse, W."Cytotoxicity of 2-deoxy-D-glucose and its tetra-acetate ester in tumoral cell lines". Oncology Reports 4.6 (1997): 1295-1299.
Chicago
Delvaux, A., Kadiata, M., Malaisse, W."Cytotoxicity of 2-deoxy-D-glucose and its tetra-acetate ester in tumoral cell lines". Oncology Reports 4, no. 6 (1997): 1295-1299. https://doi.org/10.3892/or.4.6.1295