Microsatellite instability is rarely detected in oesophageal adenocarcinoma

  • Authors:
    • K Dolan
    • J Garde
    • S Walker
    • R Sutton
    • J Gosney
    • J Field
  • View Affiliations

  • Published online on: November 1, 1997     https://doi.org/10.3892/or.4.6.1319
  • Pages: 1319-1322
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Abstract

Microsatellite instability and the replication error phenotype are characteristic of hereditary non-polyposis colorectal cancer and have also been described in certain sporadic carcinomas. Seventy-four microsatellite DNA markers, covering all non-acrocentric autosomal chromosome arms, were used to determine the frequency of microsatellite instability in adenocarcinoma of the oesophagus. Nine of 23 cases (39%) of oesophageal adenocarcinoma demonstrated microsatellite alterations with at least 1 marker, but only 2 cases (9%) displayed alterations with multiple markers. Hence, microsatellite instability is rarely detected in oesophageal adenocarcinomas and is unlikely to play a major role in its development.

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November 1997
Volume 4 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Dolan K, Garde J, Walker S, Sutton R, Gosney J and Field J: Microsatellite instability is rarely detected in oesophageal adenocarcinoma. Oncol Rep 4: 1319-1322, 1997
APA
Dolan, K., Garde, J., Walker, S., Sutton, R., Gosney, J., & Field, J. (1997). Microsatellite instability is rarely detected in oesophageal adenocarcinoma. Oncology Reports, 4, 1319-1322. https://doi.org/10.3892/or.4.6.1319
MLA
Dolan, K., Garde, J., Walker, S., Sutton, R., Gosney, J., Field, J."Microsatellite instability is rarely detected in oesophageal adenocarcinoma". Oncology Reports 4.6 (1997): 1319-1322.
Chicago
Dolan, K., Garde, J., Walker, S., Sutton, R., Gosney, J., Field, J."Microsatellite instability is rarely detected in oesophageal adenocarcinoma". Oncology Reports 4, no. 6 (1997): 1319-1322. https://doi.org/10.3892/or.4.6.1319