Microsatellite instability is rarely detected in oesophageal adenocarcinoma
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- Published online on: November 1, 1997 https://doi.org/10.3892/or.4.6.1319
- Pages: 1319-1322
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Abstract
Microsatellite instability and the replication error phenotype are characteristic of hereditary non-polyposis colorectal cancer and have also been described in certain sporadic carcinomas. Seventy-four microsatellite DNA markers, covering all non-acrocentric autosomal chromosome arms, were used to determine the frequency of microsatellite instability in adenocarcinoma of the oesophagus. Nine of 23 cases (39%) of oesophageal adenocarcinoma demonstrated microsatellite alterations with at least 1 marker, but only 2 cases (9%) displayed alterations with multiple markers. Hence, microsatellite instability is rarely detected in oesophageal adenocarcinomas and is unlikely to play a major role in its development.