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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 1997 Volume 4 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1997 Volume 4 Issue 6

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Article

Low molecular thymic peptides improve the deficient immunocytotoxicity of mononuclear cells from tumor patients in vitro

  • Authors:
    • E Klaus
    • R Stange
    • M Kalden
    • K Krasagakis
    • H Maurer

  • View Affiliations / Copyright

    Affiliations: FREE UNIV BERLIN,INST PHARM,D-12169 BERLIN,GERMANY. FREE UNIV BERLIN,KRANKENHAUS MOABIT,KLIN NAT HEILKUNDE,D-10559 BERLIN,GERMANY. FREE UNIV BERLIN,KLINIKUM BENJAMIN FRANKLIN,D-12200 BERLIN,GERMANY.
  • Pages: 1343-1347
    |
    Published online on: November 1, 1997
       https://doi.org/10.3892/or.4.6.1343
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Abstract

We studied, in vitro, the stimulating effects of a commercial preparation of low molecular thymic peptides (TP) on the immunocytotoxicity of peripheral blood lymphocytes and monocytes from patients with breast tumors, melanoma and colorectal tumors. On average, tumor patients showed a lower natural killer (NK), lymphokine (IL-2) activated killer (LAK) cell and basic tumoristatic activity of monocytes, compared with healthy donors. There was no correlation between the NK-cell number and the NK-cell activity of the tumor patients. The TP showed no effects on the NK-cell activity in any group, yet elevated the deficient LAK-cell activity of tumor patients and that of healthy donors. On monocytes, TP enhanced the deranged tumoristatic activity only in tumor patients, while being slightly inhibitory on control monocytes. Dividing the donors on the basis of the TP effects on cytotoxicity of the mononuclear cells into TP-nonresponders and TP-responders, a higher number of TP-responders was found among tumor patients, compared with healthy donors. Moreover, a higher number of TP-nonresponders were observed with lymphocytes from colorectal tumor patients at advanced tumor stage. Therefore, on the basis of the applied immunocytotoxic assays, these results may provide a basis for selecting tumor patients, who may respond to TP in immunotherapy protocols.

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Copy and paste a formatted citation
Spandidos Publications style
Klaus E, Stange R, Kalden M, Krasagakis K and Maurer H: Low molecular thymic peptides improve the deficient immunocytotoxicity of mononuclear cells from tumor patients in vitro. Oncol Rep 4: 1343-1347, 1997.
APA
Klaus, E., Stange, R., Kalden, M., Krasagakis, K., & Maurer, H. (1997). Low molecular thymic peptides improve the deficient immunocytotoxicity of mononuclear cells from tumor patients in vitro. Oncology Reports, 4, 1343-1347. https://doi.org/10.3892/or.4.6.1343
MLA
Klaus, E., Stange, R., Kalden, M., Krasagakis, K., Maurer, H."Low molecular thymic peptides improve the deficient immunocytotoxicity of mononuclear cells from tumor patients in vitro". Oncology Reports 4.6 (1997): 1343-1347.
Chicago
Klaus, E., Stange, R., Kalden, M., Krasagakis, K., Maurer, H."Low molecular thymic peptides improve the deficient immunocytotoxicity of mononuclear cells from tumor patients in vitro". Oncology Reports 4, no. 6 (1997): 1343-1347. https://doi.org/10.3892/or.4.6.1343
Copy and paste a formatted citation
x
Spandidos Publications style
Klaus E, Stange R, Kalden M, Krasagakis K and Maurer H: Low molecular thymic peptides improve the deficient immunocytotoxicity of mononuclear cells from tumor patients in vitro. Oncol Rep 4: 1343-1347, 1997.
APA
Klaus, E., Stange, R., Kalden, M., Krasagakis, K., & Maurer, H. (1997). Low molecular thymic peptides improve the deficient immunocytotoxicity of mononuclear cells from tumor patients in vitro. Oncology Reports, 4, 1343-1347. https://doi.org/10.3892/or.4.6.1343
MLA
Klaus, E., Stange, R., Kalden, M., Krasagakis, K., Maurer, H."Low molecular thymic peptides improve the deficient immunocytotoxicity of mononuclear cells from tumor patients in vitro". Oncology Reports 4.6 (1997): 1343-1347.
Chicago
Klaus, E., Stange, R., Kalden, M., Krasagakis, K., Maurer, H."Low molecular thymic peptides improve the deficient immunocytotoxicity of mononuclear cells from tumor patients in vitro". Oncology Reports 4, no. 6 (1997): 1343-1347. https://doi.org/10.3892/or.4.6.1343
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