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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
November 1997 Volume 4 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1997 Volume 4 Issue 6

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Article

Expression pattern of gastrointestinal markers in native colorectal epithelium, lesions, and carcinomas

  • Authors:
    • C Labouvie
    • J Machado
    • F Carneiro
    • G Seitz
    • N Blin
  • View Affiliations / Copyright

    Affiliations: UNIV PORTO, INST MOL PATHOL & IMMUNOL, P-4100 OPORTO, PORTUGAL. MED CLIN, INST PATHOL, BAMBERG, GERMANY.
  • Pages: 1367-1371
    |
    Published online on: November 1, 1997
       https://doi.org/10.3892/or.4.6.1367
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Abstract

Three small peptides with a typical cysteine-rich domain (TFF or P-domain) display a specific folding structure (trefoil); they are abundantly expressed on mucosal surfaces of normal and neoplastic gastrointestinal tissues. This epithelial location coincides with mucin secretion and, although not proven beyond doubt, this association is suggestive of their function in maintenance of surface integrity. Using normal colon epithelium, premalignant lesions and tumor samples and specific antibodies we studied expression of these peptides in colorectal carcinomas. RT PCR was performed to extend the sensitivity of the assays. While coexpression of pS2, hITF, MUC1 and MUC2 was demonstrated, MUC5 was absent and no simultaneous activity of pS2 and SML1 (as in gastric mucosa and carcinoma) was noted in rectal tumors. Actively transcribed and expressed cytokeratin 20 and GAPDH were used as experimental controls for immunostaining and RT-PCR, respectively.

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Copy and paste a formatted citation
Spandidos Publications style
Labouvie C, Machado J, Carneiro F, Seitz G and Blin N: Expression pattern of gastrointestinal markers in native colorectal epithelium, lesions, and carcinomas. Oncol Rep 4: 1367-1371, 1997.
APA
Labouvie, C., Machado, J., Carneiro, F., Seitz, G., & Blin, N. (1997). Expression pattern of gastrointestinal markers in native colorectal epithelium, lesions, and carcinomas. Oncology Reports, 4, 1367-1371. https://doi.org/10.3892/or.4.6.1367
MLA
Labouvie, C., Machado, J., Carneiro, F., Seitz, G., Blin, N."Expression pattern of gastrointestinal markers in native colorectal epithelium, lesions, and carcinomas". Oncology Reports 4.6 (1997): 1367-1371.
Chicago
Labouvie, C., Machado, J., Carneiro, F., Seitz, G., Blin, N."Expression pattern of gastrointestinal markers in native colorectal epithelium, lesions, and carcinomas". Oncology Reports 4, no. 6 (1997): 1367-1371. https://doi.org/10.3892/or.4.6.1367
Copy and paste a formatted citation
x
Spandidos Publications style
Labouvie C, Machado J, Carneiro F, Seitz G and Blin N: Expression pattern of gastrointestinal markers in native colorectal epithelium, lesions, and carcinomas. Oncol Rep 4: 1367-1371, 1997.
APA
Labouvie, C., Machado, J., Carneiro, F., Seitz, G., & Blin, N. (1997). Expression pattern of gastrointestinal markers in native colorectal epithelium, lesions, and carcinomas. Oncology Reports, 4, 1367-1371. https://doi.org/10.3892/or.4.6.1367
MLA
Labouvie, C., Machado, J., Carneiro, F., Seitz, G., Blin, N."Expression pattern of gastrointestinal markers in native colorectal epithelium, lesions, and carcinomas". Oncology Reports 4.6 (1997): 1367-1371.
Chicago
Labouvie, C., Machado, J., Carneiro, F., Seitz, G., Blin, N."Expression pattern of gastrointestinal markers in native colorectal epithelium, lesions, and carcinomas". Oncology Reports 4, no. 6 (1997): 1367-1371. https://doi.org/10.3892/or.4.6.1367
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