Enhancement of the effect of an angiogenesis inhibitor on murine tumors by hyperthermia.

  • Authors:
    • S Ikeda
    • K Akagi
    • T Shiraishi
    • Y Tanaka
  • View Affiliations

  • Published online on: January 1, 1998     https://doi.org/10.3892/or.5.1.181
  • Pages: 181-185
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Abstract

We investigated the effect of angiogenesis inhibitors (FR118487 and TNP-470) on two murine tumors (FM3A and SCC-VII) with and without hyperthermia. When angiogenesis inhibitors were administered immediately after tumor implantations there was no tumor growth. As the tumor diameter increased, the antitumor effect of the inhibitors decreased. When FR118487 was combined with hyperthermia, the antitumor effect was potentiated. This study suggested that angiogenesis inhibitors show their maximal effect against small tumors and have increased activity when combined with hyperthermia.

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Jan-Feb 1998
Volume 5 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ikeda S, Akagi K, Shiraishi T and Tanaka Y: Enhancement of the effect of an angiogenesis inhibitor on murine tumors by hyperthermia.. Oncol Rep 5: 181-185, 1998
APA
Ikeda, S., Akagi, K., Shiraishi, T., & Tanaka, Y. (1998). Enhancement of the effect of an angiogenesis inhibitor on murine tumors by hyperthermia.. Oncology Reports, 5, 181-185. https://doi.org/10.3892/or.5.1.181
MLA
Ikeda, S., Akagi, K., Shiraishi, T., Tanaka, Y."Enhancement of the effect of an angiogenesis inhibitor on murine tumors by hyperthermia.". Oncology Reports 5.1 (1998): 181-185.
Chicago
Ikeda, S., Akagi, K., Shiraishi, T., Tanaka, Y."Enhancement of the effect of an angiogenesis inhibitor on murine tumors by hyperthermia.". Oncology Reports 5, no. 1 (1998): 181-185. https://doi.org/10.3892/or.5.1.181