Deletion mapping in breast tumor cell lines points to two distinct tumor-suppressor genes in the 1p32-pter region, one of deleted regions (1p36.2) being located within the consensus region of LOH in neuroblastoma.

Bieche,I; Khodja,A; Lidereau,R

doi:10.3892/or.5.1.267

Jan-Feb 1998 Volume 5 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

Jan-Feb 1998 Volume 5 Issue 1

Full Size Image

Article

Deletion mapping in breast tumor cell lines points to two distinct tumor-suppressor genes in the 1p32-pter region, one of deleted regions (1p36.2) being located within the consensus region of LOH in neuroblastoma.

Authors:
- I Bieche
- A Khodja
- R Lidereau
View Affiliations / Copyright

Affiliations: Laboratoire d'Oncogénétique, Centre René Huguenin, St-Cloud, France.
Pages: 267-339
|
Published online on: January 1, 1998

https://doi.org/10.3892/or.5.1.267
Expand metrics +

Abstract

Cytogenetic and molecular studies have suggested that the 1p32-pter region might contain tumor-suppressor genes involved in the pathogenesis of breast cancer and other malignancies. Isolation of these genes could be facilitated by studying tumor cell lines with well-defined deleted regions. We examined deletions on chromosome 1p in 10 breast tumor cell lines, using a panel of 36 polymorphic markers located mainly in the 1p32-pter region, that comprised microsatellite, restriction fragment length polymorphism (RFLP) and variable number of tandem repeat (VNTR) markers. Two regions of interest were clearly identified: one (27 cM apart) is located at 1p32-p34 and reduces the smallest common deleted region (SCDR) to 8 cM if recorded the previous 1p LOH studies from primary breast tumors and the other (15 cM) is located at 1p36.2, within the 'consensus region of LOH' in neuroblastoma. These results show that the study of cell lines can refine SCDRs identified in primary tumors and can be used to identify putative homozygous deletions and to study the expression and structure alterations of candidate tumor-suppressor genes in these deleted regions.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Deletion mapping in breast tumor cell lines points to two distinct tumor-suppressor genes in the 1p32-pter region, one of deleted regions (1p36.2) being located within the consensus region of LOH in neuroblastoma.

This article is mentioned in:

Abstract

Related Articles