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Enhancement of CDDP cytotoxicity by caffeine is characterized by apoptotic cell death.

  • Authors:
    • M Takahashi
    • Y Yamamoto
    • S Hatori
    • M Shiozawa
    • M Suzuki
    • Y Rino
    • T Amano
    • T Imada

  • View Affiliations

  • Published online on: January 1, 1998     https://doi.org/10.3892/or.5.1.53
  • Pages: 53-59
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Abstract

Through the use of STKM-1 human stomach cancer cells, we investigated the enhancement of the anti-tumor effect and the apoptosis induction of the CDDP and caffeine combination. Even when the concentration of CDDP was low, CDDP significantly decreased the proliferation of STKM-1 human stomach cancer cells, thus confirming the synergistic effect of the CDDP and caffeine group. The apoptotic labeling index of the CDDP plus caffeine combination was significantly higher than that of the CDDP group. In conclusion, caffeine enhanced the effect of CDDP by not only inhibiting DNA repairs but also inducing apoptosis.

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Jan-Feb 1998
Volume 5 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 4.2
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Takahashi M, Yamamoto Y, Hatori S, Shiozawa M, Suzuki M, Rino Y, Amano T and Imada T: Enhancement of CDDP cytotoxicity by caffeine is characterized by apoptotic cell death.. Oncol Rep 5: 53-59, 1998
APA
Takahashi, M., Yamamoto, Y., Hatori, S., Shiozawa, M., Suzuki, M., Rino, Y. ... Imada, T. (1998). Enhancement of CDDP cytotoxicity by caffeine is characterized by apoptotic cell death.. Oncology Reports, 5, 53-59. https://doi.org/10.3892/or.5.1.53
MLA
Takahashi, M., Yamamoto, Y., Hatori, S., Shiozawa, M., Suzuki, M., Rino, Y., Amano, T., Imada, T."Enhancement of CDDP cytotoxicity by caffeine is characterized by apoptotic cell death.". Oncology Reports 5.1 (1998): 53-59.
Chicago
Takahashi, M., Yamamoto, Y., Hatori, S., Shiozawa, M., Suzuki, M., Rino, Y., Amano, T., Imada, T."Enhancement of CDDP cytotoxicity by caffeine is characterized by apoptotic cell death.". Oncology Reports 5, no. 1 (1998): 53-59. https://doi.org/10.3892/or.5.1.53