The expression of MMP-2 and TIMP-2 in patients with colorectal adenocarcinoma invaded to the submucosal and proper muscle layer.

Mukai,M; Sadahiro,S; Tokunaga,N; Ishizu,K; Ito,I; Kameya,T; Ishikawa,K; Iwase,H; Suzuki,T; Kimura,T; Ishida,H; Tajima,T; Makuuchi,H

doi:10.3892/or.5.2.335

The expression of MMP-2 and TIMP-2 in patients with colorectal adenocarcinoma invaded to the submucosal and proper muscle layer.

Authors:
- M Mukai
- S Sadahiro
- N Tokunaga
- K Ishizu
- I Ito
- T Kameya
- K Ishikawa
- H Iwase
- T Suzuki
- T Kimura
- H Ishida
- T Tajima
- H Makuuchi
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Affiliations: Department of Surgery, Tokai University, School of Medicine, 8th Floor, Bohseidai, Isehara, Kanagawa, 259-1143, Japan.
Published online on: March 1, 1998 https://doi.org/10.3892/or.5.2.335
Pages: 335-375

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Abstract

The expression of MMP-2 and TIMP-2 was examined immunohistochemically in a total of 87 colorectal cancer patients. The expression of MMP-2 was in cancer cells: 76.5% (sm), 16.7% (pm), in cancer interstitial region: 92.2% (sm), 58.3% (pm), in transitional mucosal cells: 74.3% (sm), 17.1% (pm) and in transitional mucosal interstitial region: 80.0% (sm), 31.4% (pm). The expression of TIMP-2 was in cancer cells: 41.2% (sm), 16.7% (pm), in cancer interstitial region: 82.4% (sm), 69.4% (pm), in transitional mucosal cells: 57.1% (sm), 22.9% (pm) and in transitional mucosal interstitial region: 89.3% (sm), 57.1% (pm). These results suggest that the expression of MMP-2 and TIMP-2 is induced in the sm cancer stage and is closely related to interactions in the cancer interstitial region for invasion and metastasis in patients with colorectal adenocarcinoma.