The expression of urokinase type plasminogen activator is a novel prognostic factor in dukes B and C colorectal cancer.

  • Authors:
    • S J Kim
    • E Shiba
    • F Tsukamoto
    • M Izukura
    • T Taguchi
    • K Yoneda
    • Y Tanji
    • Y Kimoto
    • S I Takai
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/or.5.2.431
  • Pages: 431-436
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Abstract

Urokinase type plasminogen activator (u-PA) secreted by cancer cells is considered to play a key role in promoting invasion and metastasis of cancer cells. This study was designed to evaluate the expression and prognostic value of u-PA in Dukes B and C colorectal cancer. u-PA expression was investigated in 57 Dukes B or C colorectal cancers using a monoclonal antibody against u-PA. u-PA expression was mainly observed on the cytoplasm of cancer cells, and was associated with relapse, especially hematogenous metastasis (p=0.025, the chi2 test). Patients with high u-PA expression had a lower rate of DFS (9/22 events) compared to those with low u-PA expression (6/35 events) (p=0.061, log-rank test). This study demonstrated that u-PA expression might be a novel prognostic factor in Dukes B and C colorectal cancer.

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Mar-Apr 1998
Volume 5 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kim S, Shiba E, Tsukamoto F, Izukura M, Taguchi T, Yoneda K, Tanji Y, Kimoto Y and Takai S: The expression of urokinase type plasminogen activator is a novel prognostic factor in dukes B and C colorectal cancer.. Oncol Rep 5: 431-436, 1998
APA
Kim, S., Shiba, E., Tsukamoto, F., Izukura, M., Taguchi, T., Yoneda, K. ... Takai, S. (1998). The expression of urokinase type plasminogen activator is a novel prognostic factor in dukes B and C colorectal cancer.. Oncology Reports, 5, 431-436. https://doi.org/10.3892/or.5.2.431
MLA
Kim, S., Shiba, E., Tsukamoto, F., Izukura, M., Taguchi, T., Yoneda, K., Tanji, Y., Kimoto, Y., Takai, S."The expression of urokinase type plasminogen activator is a novel prognostic factor in dukes B and C colorectal cancer.". Oncology Reports 5.2 (1998): 431-436.
Chicago
Kim, S., Shiba, E., Tsukamoto, F., Izukura, M., Taguchi, T., Yoneda, K., Tanji, Y., Kimoto, Y., Takai, S."The expression of urokinase type plasminogen activator is a novel prognostic factor in dukes B and C colorectal cancer.". Oncology Reports 5, no. 2 (1998): 431-436. https://doi.org/10.3892/or.5.2.431