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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Mar-Apr 1998 Volume 5 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Mar-Apr 1998 Volume 5 Issue 2

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Article

Induction of gastrin releasing peptide by all-trans retinoic acid in small cell lung cancer cells.

  • Authors:
    • R K Ravi
    • F M Scott
    • F Cuttitta
    • E Weber
    • G P Kalemkerian
    • B D Nelkin
    • M Mabry
  • View Affiliations / Copyright

    Affiliations: The Oncology Center, The Johns Hopkins University Medical School, Baltimore, MD 21287, USA.
  • Pages: 497-998
    |
    Published online on: March 1, 1998
       https://doi.org/10.3892/or.5.2.497
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Abstract

All-trans retinoic acid (RA) has been shown to inhibit cell proliferation while increasing neuroendocrine differentiation in small cell lung cancer (SCLC) cells. RA and related compounds are rapidly becoming integrated into clinical trials to prevent lung cancers and other aerodigestive neoplasms. We found that expression of gastrin releasing peptide (GRP), which can promote lung tumorigenesis in model systems, was increased by RA in SCLC cells which have functional retinoid signaling. In SCLC cells that possess functional GRP receptors, ectopic expression of RARc increased GRP expression and augmented cloning efficiency, demonstrating that these maneuvers result in biologically active GRP. SCLC cells with defects in RA pathway signaling did not efficiently induce GRP upon RA exposure. In these cells, transfection of RARs rendered the cells competent to induce GRP upon RA exposure. These data show that activation of intact retinoid signaling by RA can induce GRP, a growth factor that can act as a tumor promoter. Our findings suggest the possibility that retinoids may increase, rather than decrease, lung cancer risks in some individuals.

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Copy and paste a formatted citation
Spandidos Publications style
Ravi R, Scott F, Cuttitta F, Weber E, Kalemkerian G, Nelkin B and Mabry M: Induction of gastrin releasing peptide by all-trans retinoic acid in small cell lung cancer cells.. Oncol Rep 5: 497-998, 1998.
APA
Ravi, R., Scott, F., Cuttitta, F., Weber, E., Kalemkerian, G., Nelkin, B., & Mabry, M. (1998). Induction of gastrin releasing peptide by all-trans retinoic acid in small cell lung cancer cells.. Oncology Reports, 5, 497-998. https://doi.org/10.3892/or.5.2.497
MLA
Ravi, R., Scott, F., Cuttitta, F., Weber, E., Kalemkerian, G., Nelkin, B., Mabry, M."Induction of gastrin releasing peptide by all-trans retinoic acid in small cell lung cancer cells.". Oncology Reports 5.2 (1998): 497-998.
Chicago
Ravi, R., Scott, F., Cuttitta, F., Weber, E., Kalemkerian, G., Nelkin, B., Mabry, M."Induction of gastrin releasing peptide by all-trans retinoic acid in small cell lung cancer cells.". Oncology Reports 5, no. 2 (1998): 497-998. https://doi.org/10.3892/or.5.2.497
Copy and paste a formatted citation
x
Spandidos Publications style
Ravi R, Scott F, Cuttitta F, Weber E, Kalemkerian G, Nelkin B and Mabry M: Induction of gastrin releasing peptide by all-trans retinoic acid in small cell lung cancer cells.. Oncol Rep 5: 497-998, 1998.
APA
Ravi, R., Scott, F., Cuttitta, F., Weber, E., Kalemkerian, G., Nelkin, B., & Mabry, M. (1998). Induction of gastrin releasing peptide by all-trans retinoic acid in small cell lung cancer cells.. Oncology Reports, 5, 497-998. https://doi.org/10.3892/or.5.2.497
MLA
Ravi, R., Scott, F., Cuttitta, F., Weber, E., Kalemkerian, G., Nelkin, B., Mabry, M."Induction of gastrin releasing peptide by all-trans retinoic acid in small cell lung cancer cells.". Oncology Reports 5.2 (1998): 497-998.
Chicago
Ravi, R., Scott, F., Cuttitta, F., Weber, E., Kalemkerian, G., Nelkin, B., Mabry, M."Induction of gastrin releasing peptide by all-trans retinoic acid in small cell lung cancer cells.". Oncology Reports 5, no. 2 (1998): 497-998. https://doi.org/10.3892/or.5.2.497
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