Adjuvant therapy for gastric adenocarcinoma with the apoptosis-inducing human monoclonal antibody SC-1: first clinical and histopathological results.

  • Authors:
    • H P Vollmers
    • U Zimmermann
    • V Krenn
    • W Timmermann
    • B Illert
    • F Hensel
    • R Hermann
    • A Thiede
    • M Wilhelm
    • H Rückle-Lanz
    • L Reindl
    • H K Müller-Hermelink
  • View Affiliations

  • Published online on: May 1, 1998     https://doi.org/10.3892/or.5.3.549
  • Pages: 549-601
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Abstract

In a first clinical trial with the apoptosis-inducing human antibody SC-1 eight patients with poorly differentiated stomach adenocarcinoma of diffuse-type received 20 or 30 mg of purified SC-1 antibody intravenously, followed 24 or 48 h later by gastrectomy and lymphadenectomy. In seven cases a significant induction of apoptotic activity was measured in primary tumors as compared with earlier biopsy material and in five patients a significant regression of tumor mass could be determined histopathologically. No toxic crossreactivity was observed with normal tissue or organs of patients.

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May-Jun 1998
Volume 5 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Vollmers H, Zimmermann U, Krenn V, Timmermann W, Illert B, Hensel F, Hermann R, Thiede A, Wilhelm M, Rückle-Lanz H, Rückle-Lanz H, et al: Adjuvant therapy for gastric adenocarcinoma with the apoptosis-inducing human monoclonal antibody SC-1: first clinical and histopathological results.. Oncol Rep 5: 549-601, 1998
APA
Vollmers, H., Zimmermann, U., Krenn, V., Timmermann, W., Illert, B., Hensel, F. ... Müller-Hermelink, H. (1998). Adjuvant therapy for gastric adenocarcinoma with the apoptosis-inducing human monoclonal antibody SC-1: first clinical and histopathological results.. Oncology Reports, 5, 549-601. https://doi.org/10.3892/or.5.3.549
MLA
Vollmers, H., Zimmermann, U., Krenn, V., Timmermann, W., Illert, B., Hensel, F., Hermann, R., Thiede, A., Wilhelm, M., Rückle-Lanz, H., Reindl, L., Müller-Hermelink, H."Adjuvant therapy for gastric adenocarcinoma with the apoptosis-inducing human monoclonal antibody SC-1: first clinical and histopathological results.". Oncology Reports 5.3 (1998): 549-601.
Chicago
Vollmers, H., Zimmermann, U., Krenn, V., Timmermann, W., Illert, B., Hensel, F., Hermann, R., Thiede, A., Wilhelm, M., Rückle-Lanz, H., Reindl, L., Müller-Hermelink, H."Adjuvant therapy for gastric adenocarcinoma with the apoptosis-inducing human monoclonal antibody SC-1: first clinical and histopathological results.". Oncology Reports 5, no. 3 (1998): 549-601. https://doi.org/10.3892/or.5.3.549